Research progress of CD13-targeted molecular probe in tumor neovascularization imaging and therapy

中华核医学与分子影像杂志 Pub Date : 2019-11-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2019.11.013

Minghao Wu, Yanyan Zhang, Lin Cao, Xuening Zhang

引用次数: 0

Abstract

Tumor neovascularization plays an important role in the occurrence, development and metastasis of cancer. Non-invasive quantification and detection of tumor neovascularization is crucial for early diagnosis and prognosis assessment of cancer. Targeted molecular imaging has arisen in vascular targeting imaging and precise treatment based on the molecular characteristics of neovascularization. Aminopeptidase N (APN, or CD13) is a multifunctional membrane-bound exopeptidase that is overexpressed in neovascular endothelial cells and some tumor cells but rarely expressed in normal blood vessels, which makes it a potential target for tumor neovascularization imaging and anti-angiogenic therapy. This review summarizes the application progress and the future development trend of target molecular imaging and precise treatment based on CD13. Key words: Neoplasms; Neovascularization, pathologic; Angiogenesis inhibitors; Antigens, CD13; Trends

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cd13靶向分子探针在肿瘤新生血管成像及治疗中的研究进展

肿瘤新生血管在肿瘤的发生、发展和转移中起着重要作用。肿瘤新生血管的无创量化和检测对于肿瘤的早期诊断和预后评估至关重要。靶向分子成像在血管靶向成像和基于新生血管分子特征的精准治疗中兴起。氨肽酶N (APN，或CD13)是一种多功能的膜结合外肽酶，在新生血管内皮细胞和一些肿瘤细胞中过表达，但在正常血管中很少表达，这使其成为肿瘤新生血管成像和抗血管生成治疗的潜在靶点。本文综述了基于CD13的靶分子成像及精准治疗的应用进展及未来发展趋势。关键词:肿瘤;新血管形成,病理;血管生成抑制剂;抗原CD13;趋势

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

0.00%

发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.