Efek asam alfa lipoat terhadap insulitis pada tikus diabetes melitus tipe 2

Jurnal Gizi Klinik Indonesia Pub Date : 2019-10-25 DOI:10.22146/ijcn.31701

Ismawati Ismawati, Mukhyarjon Mukhyarjon, Ilhami Romus, Dinda Sonia

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引用次数: 1

Abstract

Effect of alpha lipoic acid on insulitis in type 2 diabetic ratBackground: The damaging of β cell causes hyperglycemia. Β cell damaged as insulitis happens because of the increase of free radical and the decrease of endogen antioxidant that caused oxidative stress.Objective: The goal of this research was to find out the effect of alpha lipoic acid (ALA) on pancreas Langerhans island’s histopathology in type 2 diabetic rats.Methods: This was an experimental laboratory study with post test only design. Fifteen adult male rats of Wistar strain were segregated into three groups (n=5) labeled as control, type 2 diabetes (DM), and DM+ALA. The experiment was designed for 3 weeks. The measured parameter was insulitis level on pancreas Langerhans island of groups labeled.Results: The statistical test result showed there was the significant difference between control and type 2 diabetes group (p=0,005), but there was no significant difference between DM and DM+ ALA group (p=0,549).Conclusions: Although not statistically significant, giving ALA 60 mg/kg body weight for 3 weeks decreased the degree of insulitis in diabetic rats.

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2型糖尿病老鼠的脂肪酸对糖尿病的影响

硫辛酸对2型糖尿病大鼠胰岛素炎的影响研究背景:β细胞损伤引起高血糖。Β胰岛素引起的细胞损伤是由于自由基的增加和内源性抗氧化剂的减少而引起的氧化应激。目的:探讨α硫辛酸(ALA)对2型糖尿病大鼠胰腺朗格汉斯岛组织病理学的影响。方法:采用单纯后测设计的实验室实验研究。选取Wistar株成年雄性大鼠15只，分为对照组、2型糖尿病(DM)组和DM+ALA组(n=5)。试验设计时间为3周。测量参数为标记组胰腺朗格汉斯岛胰岛素水平。结果:统计检验结果显示，对照组与2型糖尿病组比较差异有统计学意义(p= 0.005)， DM组与DM+ ALA组比较差异无统计学意义(p= 0.549)。结论:虽然没有统计学意义，但给予ALA 60 mg/kg体重3周可以降低糖尿病大鼠的胰岛素程度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Jurnal Gizi Klinik Indonesia

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审稿时长

4 weeks