Smart terbinafine recent nano-advances in delivery of terbinafine

Abstract

Terbinafine (TBF) is a drug with well-known antifungal properties effective against skin dermatophyte infections and nail particularly in treatment of pityriasis (tinea) vesicolor due to Malassezia furfur. Terbinafine topical administration is often recommended because commercial conventional terbinafine hydrochloride tablets are more expensive and have potential for significant adverse effects. Only less than 5% of terbinafine is absorbed in conventional topical forms. Novel nano-formulation approaches would be an efficient way to enhance penetration and abortion of topical drugs and eliminate limitations of conventional drug delivery systems. As conclusion, we believe that administering the Terbinafine in nano-formulations, according to different studies, could increases penetration of TBF through stratum corneum and viable epidermis and light the path of nano-structural delivery system in clinical application. Present overview aims to evaluate nano-strategies applied to improve permeation profile and terbinafine skin delivery.