Predicting cognitive impairment and psycho-emotional disorders in Multiple Sclerosis patients according to MRI findings

Q4 Medicine

Romanian Journal of Neurology/ Revista Romana de Neurologie Pub Date : 2022-12-31 DOI:10.37897/rjn.2022.4.11

T. Odintsova, O. Kopchak

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引用次数: 0

Abstract

Objectives. The aim of our study was to assess the probability of cognitive impairment (CI) in general and in separate domains, depression, anxiety and sleep disorders onset depending on their association with MRI findings in patients with multiple sclerosis (MS). Materials and methods. 137 patients with MS were enrolled into the study. All participants were divided into two groups: group A included study subjects with relapsing remitting multiple sclerosis (RRMS) and B consisted of patients with secondary progressive multiple sclerosis (SPMS). Results. Participants with progressive forms of MS had a higher risk of CI development compare to the patients with RRMS (p=0,0361). Memory decline onset depended on the presence of the brain atrophy in combination with lesions of the parietal lobe (OR=2.74 (0.85-8.77), p <0.0001) in RRMS cases, furthermore, on presence of combined demyelination in temporal lobe with corpus callosum (OR=17.33 (2.92-103.02), p=0.0006) and parietal lobe separately (OR=7.5 (1.14-49.26), p=0.0239) in patients with SPMS. Conclusions. CI and psycho-emotional disorders can be predicted by means of MRI findings and potentially prevented.

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根据MRI结果预测多发性硬化症患者的认知障碍和心理情绪障碍

目标。我们研究的目的是评估多发性硬化症（MS）患者在一般和不同领域出现认知障碍（CI）、抑郁、焦虑和睡眠障碍的可能性，这取决于它们与MRI结果的关系。材料和方法。137名MS患者被纳入研究。所有参与者被分为两组：A组包括复发-缓解型多发性硬化症（RRMS）的研究受试者，B组包括继发性进行性多发性痴呆症（SPMS）的患者。后果与RRMS患者相比，患有进行性MS的参与者发生CI的风险更高（p=0.0361）。在RRMS病例中，记忆衰退的发生取决于脑萎缩与顶叶病变的存在（OR=2.74（0.85-8.77），p<0.0001），此外，在SPMS患者中，还取决于颞叶与胼胝体的联合脱髓鞘的存在（OR=17.33（2.92-103.02），p=0.0006）和顶叶分别存在（OR=7.5（1.14-49.26），p=0.0239）。结论。CI和心理情绪障碍可以通过MRI检查结果进行预测，并有可能预防。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Romanian Journal of Neurology/ Revista Romana de Neurologie Medicine-Neurology (clinical)

CiteScore

0.40

自引率

0.00%

发文量

审稿时长

4 weeks

期刊介绍： ROMANIAN JOURNAL OF NEUROLOGY (Revista Română de Neurologie), the official journal of the Romanian Society of Neurology, was founded in 2001, being a prestigious scientific journal that provides a high quality in terms of scientific content, but also the editorial and graphic aspect, both through an impartial process of selection, evaluation and correction of articles (peer review procedure), as well as providing editorial, graphic and printing conditions at the highest level. In order to increase the scientific standards of the journal, special attention was paid to the improvement of the quality of the published materials. Guidance articles, clinical trials and case studies are structured in several sections: reviews, original articles, case reports, images in neurology. All articles are published entirely in English. A team of reputable medical professionals in the field of neurology is involved in a rigorous peer review process that complies with international ethics and quality rules in the academic world.