The 2016 revision of the World Health Organization classification of tumors of the central nervous system: Evidence-based and morphologically flawed

Abstract

The 2016 revision of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS) was one of the first to introduce genetic subtyping in the histological groups of these tumors.[1] However, since its introduction and based on the lack of histological criteria in the article summary of the classification, which is often cited as the classification itself, nonpathologists have become extremely ignorant of the difficulties in identifying these rare and diverse tumor entries.[2]