Research progress of biopolymers combined with stem cells in the repair of intrauterine adhesions

IF 6.1 3区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nanotechnology Reviews Pub Date : 2023-01-01 DOI:10.1515/ntrev-2022-0529

Zhujie Wang, Juanjuan Jiang, Xingmiao Li, Mo Chen, Mengjia Yu, Meijun Guo, Ning Wang, Yangyang Li, Xiuxiu Jiang

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引用次数: 0

Abstract

Abstract Asherman syndrome (AS) refers to the loss of endometrial stem cells and matrix hyperplasia caused by endometrial basal layer injury. Its common clinical manifestations include narrowing of the uterine cavity, reduction in menstrual volume, abdominal pain, amenorrhea, and infertility. According to the cause of AS, treatment includes a mechanical barrier and functional recovery. Because the functional recovery of the endometrium depends on the regeneration of endometrial epithelial cells, in the absence of cell involvement, the effect of repair by mechanical removal of adhesions is limited. Recently, tissue engineering and stem cell therapy have achieved promising progress in the recovery of organ function. Biological scaffolds have been applied to encapsulated stem cells as a therapeutic strategy for repairing endometrial damage. This review explains the progress of intrauterine materials and stem cell combined biopolymers in the study of AS and emphasizes the evidence from animal and clinical trials. Graphical abstract

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生物聚合物与干细胞联合修复宫内粘连的研究进展

摘要Asherman综合征是指由子宫内膜基底层损伤引起的子宫内膜干细胞丢失和基质增生。其常见的临床表现包括宫腔缩小、月经量减少、腹痛、闭经和不孕。根据AS的病因，治疗包括机械屏障和功能恢复。由于子宫内膜的功能恢复取决于子宫内膜上皮细胞的再生，在没有细胞参与的情况下，通过机械去除粘连进行修复的效果有限。近年来，组织工程和干细胞治疗在器官功能恢复方面取得了可喜的进展。生物支架已被应用于包封干细胞，作为修复子宫内膜损伤的治疗策略。这篇综述解释了宫内材料和干细胞结合的生物聚合物在AS研究中的进展，并强调了动物和临床试验的证据。图形摘要

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来源期刊

Nanotechnology Reviews CHEMISTRY, MULTIDISCIPLINARY-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

11.40

自引率

13.50%

发文量

137

审稿时长

7 weeks

期刊介绍： The bimonthly journal Nanotechnology Reviews provides a platform for scientists and engineers of all involved disciplines to exchange important recent research on fundamental as well as applied aspects. While expert reviews provide a state of the art assessment on a specific topic, research highlight contributions present most recent and novel findings. In addition to technical contributions, Nanotechnology Reviews publishes articles on implications of nanotechnology for society, environment, education, intellectual property, industry, and politics.