The Effect of Liposome Nanocarrier Containing Scrophularia striata Extract on Burn Wound Healing in Rats

Q4 Veterinary
M. Shahraki, M. Molaei, R. Kheirandish, Pourya Mohammadi, E. Sakhaee
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引用次数: 1

Abstract

The present study was conducted to evaluate the wound healing effects of liposome nanocarrier containing Scrophularia striata extract. Seventy-two male Wistar albino rats were divided into 6 groups of 12 animals each. Rats were anesthetized, and dorsum shaved. A 100 g cylindrical copper rod of 1cm diameter was heated up to 100°C. It was placed on the skin without any pressure. Histopathological evaluation and the macroscopic size processing and analysis of the burn were employed to study the potential of wound healing in study groups. The study groups were: Positive control group (Zinc oxide treatment), treatment group (Ointment containing nanoliposomes loaded with extract Scrophularia striata), extract group (Ointment containing hydroalcoholic extract Scrophularia striata), control group of nanoliposomes (Ointment containing Nano liposomes), Eucerin control group (Ointment containing Eucerin), negative control group (No treatment). On the 5th, 10th, and 15th days after the initial operation, samples were taken from 4 rats of each group. The results showed that loaded nanoliposomes had a nanometric size and spherical morphology. Also, the wound size of the treatment group was smaller than other groups and had the best effect on repairing wound healing. Also, in other groups, positive control had a better effect on wound repair than extract, Eucerin, nano, and negative groups. According to the highest re-epithelialization, granulation tissue formation, and the lowest necrotic tissue, we could suggest that the treatment group had the best healing effect among other groups.
棘棘提取物脂质体纳米载体对大鼠烧伤创面愈合的影响
本文研究了含玄参提取物的脂质体纳米载体的创面愈合效果。将72只雄性Wistar白化大鼠分为6组,每组12只。大鼠麻醉,背部剃毛。将直径为1cm的100g圆柱形铜棒加热至100℃。它被放在皮肤上,没有任何压力。采用组织病理学评价和烧伤宏观尺寸处理分析研究各研究组创面愈合潜力。研究分组为:阳性对照组(氧化锌处理)、治疗组(含有含有玄参提取物的纳米脂质体软膏)、提取物组(含有玄参水醇提取物的软膏)、纳米脂质体对照组(含有纳米脂质体的软膏)、Eucerin对照组(含有Eucerin软膏)、阴性对照组(未处理)。于术后第5、10、15天,每组取4只大鼠标本。结果表明,负载的纳米脂质体具有纳米级大小和球形形态。治疗组创面尺寸小于其他组,修复创面愈合效果最好。在其他组中,阳性对照的创面修复效果优于提取物组、Eucerin组、纳米组和阴性组。根据再上皮化和肉芽组织形成最高,坏死组织最少的结果,我们认为治疗组的愈合效果最好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.50
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30 weeks
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