Flavonoids from Kalanchoe ×laetivirens Impair Survival and Immunity of Atta sexdens (Hymenoptera: Formicidae)

IF 0.7 Q4 CHEMISTRY, MEDICINAL

Natural Products Journal Pub Date : 2023-08-08 DOI:10.2174/2210315514666230808142940

Danival José de Souza, Márcio Silva Melo, Cynthia Lhourrana Santos Silva, Amanda Caroline Teles Tenório, Bruno Silva Melo, Rone da Silva Barbosa, R. Sarmento, Juliana Cristina Holzbach, Állefe Barbosa Cruz, Isabele Rodrigues Nascimento

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引用次数: 0

Abstract

The active secondary metabolites of various Kalanchoe species are promising for controlling insects and other agricultural pests. This study aimed to evaluate the mortality and immune responses of the leafcutter ant Atta sexdens (L.) after treatment with Kalanchoe ×laetivirens (Desc.) aqueous extract. The effects on an aquatic organism used as a bioindicator, Chironomus xanthus (Rempel), were also evaluated. Different K. ×laetivirens concentrations were prepared by dilution in honey to assess the toxicity and determine the median lethal concentration (LC50) for A. sexdens workers. The haemocytes of workers treated with a sublethal concentration (0.005 g/mL) were counted. The plant extracts induced high mortality in A. sexdens workers. All concentrations, except 0.001 g/mL, increased mortality rates. The sublethal concentration negatively affected the immune system of A. sexdens workers 48 and 72 h after ingestion. The flavonoids 4″″-acetylsagittatin A, sagittatin A and the nucleosides uridine and adenosine were identified. The LC50 of the K. ×laetivirens (128.1 mg /L) was determined for the non-target organism, C. xanthus. These natural compounds can be used in future research to plan alternative control strategies for leafcutter ants in forests and other agroecosystems.

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黄酮×laetivirens对蚁蜂生存和免疫的影响(膜翅目:蚁科)

其次生代谢产物在防治昆虫和其他农业害虫方面具有广阔的应用前景。本研究旨在评价kalanche ×laetivirens (Desc.)水提物处理后切叶蚁(Atta sexdens (L.))的死亡率和免疫反应。对一种用作生物指示剂的水生生物——黄斑Chironomus xanthus (Rempel)——的影响也进行了评价。采用蜂蜜稀释法制取不同浓度的×laetivirens，评价其毒性，测定其对雄性姬蜂工蜂的中位致死浓度(LC50)。对亚致死浓度(0.005 g/mL)处理的工人血细胞进行计数。植物提取物可引起高死亡率的工蜂。除0.001 g/mL外，所有浓度均增加了死亡率。亚致死浓度对摄入后48和72 h的雄性姬蜂免疫系统均有不良影响。鉴定了黄酮类化合物4″″-乙酰矢状苷A、矢状苷A以及核苷尿苷和腺苷。测定了K. ×laetivirens对非靶菌C. xanthus的LC50 (128.1 mg /L)。这些天然化合物可用于未来的研究，以规划森林和其他农业生态系统中切叶蚁的替代控制策略。

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来源期刊

Natural Products Journal CHEMISTRY, MEDICINAL-

CiteScore

1.70

自引率

0.00%

发文量

期刊介绍： The Natural Products Journal a peer reviewed journal, aims to publish all the latest and outstanding developments in natural products. The Natural Products Journal publishes original research articles, full-length/mini reviews, letters and guest edited issues on all aspects of research and development in the field including: isolation, purification, structure elucidation, synthesis and bioactivity of chemical compounds found in nature.