Investigation of In Vitro antiproliferative activity properties of Spartium junceum L. (Spanish broom) against MDA-MB-231 and HepG2 cancer cell lines

Fatma Tuğçe GÜRAĞAÇ DERELİ, S. Akkoç
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引用次数: 0

Abstract

Cancer is among the top global public health burdens leading to millions of deaths each year. The study aims to investigate the antiproliferative effect of Spartium junceum L. flowers on different cancer cell lines. The ethanolic extract of the flowers was prepared in the present study. Phytochemical analysis of the plant extract revealed the presence of several phenolic compounds such as cinnamic acid and its derivatives (chlorogenic, p-coumaric, ferulic acids), protocatechuic acid, epicatechin and luteolin. This extract was tested against human breast (MDA-MB-231) and liver (HepG2) cancer cell lines to find out its antiproliferative activity. It was determined that the extract was effective against both cell lines with IC50 values of 2.37 ± 0.47 and 0.98 ± 0.01 µL/mL for MDA-MB-231 and HepG2, respectively. Particularly, the extract was found to be more effective in the liver cancer cell line than the breast cancer cell line. All these obtained findings led us to believe that this medicinal plant could be a promising antiproliferative agent candidate for the treatment of human liver and breast cancers.
菝葜(Spartium junceum L.)体外抗MDA-MB-231和HepG2癌细胞增殖活性的研究
癌症是全球最大的公共卫生负担之一,每年导致数百万人死亡。本研究旨在探讨米草(Spartium junceum L.)花对不同癌细胞系的抗增殖作用。本研究制备了红花的乙醇提取物。植物化学分析表明,该植物提取物中含有肉桂酸及其衍生物(绿原酸、对香豆酸、阿魏酸)、原儿茶酸、表儿茶素和木犀草素等酚类化合物。对人乳腺(MDA-MB-231)和肝脏(HepG2)癌细胞进行了抗增殖活性试验。结果表明,该提取物对MDA-MB-231和HepG2的IC50值分别为2.37±0.47和0.98±0.01µL/mL。特别是,提取物被发现对肝癌细胞系比乳腺癌细胞系更有效。这些发现使我们相信这种药用植物可能是治疗人类肝癌和乳腺癌的一种有前途的抗增殖药物。
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来源期刊
International Journal of Secondary Metabolite
International Journal of Secondary Metabolite Biochemistry, Genetics and Molecular Biology-Biotechnology
CiteScore
1.40
自引率
0.00%
发文量
28
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