Benign nodules of the thyroid gland and 25-hydroxy-vitamin D levels in euthyroid patients.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Annals of Saudi Medicine Pub Date : 2022-03-01 Epub Date: 2022-04-07 DOI:10.5144/0256-4947.2022.83

Hacı Bolat, Aliriza Erdoğan

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引用次数: 0

Abstract

Background: The presence of nodules in the thyroid gland is common in iodine-deficient areas of the world. Recently, vitamin D levels were found to be lower than normal and sometimes deficient in malignant nodules of the thyroid.

Objective: Evaluate the relationship between the serum vitamin D levels and benign thyroid nodules in euthyroid patients.

Design: Cross-sectional.

Setting: Tertiary care center in Turkey.

Patients and methods: Patients referred to the general surgery outpatient clinic and diagnosed with thyroid nodules were the study group. The control group consisted of healthy individuals without thyroid nodules. Age, BMI, thyroid ultrasonography, serum 25-hydroxyvitamin D, free T3, free T4, thyroid stimulating hormone, calcium, magnesium, phosphorous, total protein, albumin, glucose, creatinine levels and glomerular filtration rate (GFR) were compared between groups.

Main outcome measure: Serum 25-hydroxy-vitamin D levels and size of the thyroid nodules.

Sample size and characteristics: Of 849 individuals, 453 were patients with thyroid nodules and 396 were healthy individuals.

Results: The mean serum vitamin D levels of patients with thyroid nodules were significantly lower than controls (P<.001). Serum vitamin D levels along with serum total protein levels and eGFR were independent variables associated with the presence of a thyroid nodule (P<.001, p=.005 and P=.017, respectively).

Conclusion: These findings suggest vitamin D deficiency might be one of the pathophysiologic factors in development of thyroid nodules.

Limitation: Single-center and possible information bias.

Conflicts of interest: None.

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甲状腺良性结节与正常甲状腺患者25-羟基维生素D水平的关系

背景:甲状腺结节的存在是常见的在世界缺碘地区。最近，在甲状腺恶性结节中发现维生素D水平低于正常水平，有时缺乏。目的:探讨甲状腺功能正常患者血清维生素D水平与良性甲状腺结节的关系。设计:横断面。地点:土耳其三级医疗中心。患者和方法:在普通外科门诊就诊并诊断为甲状腺结节的患者为研究组。对照组为无甲状腺结节的健康人。比较两组患者年龄、BMI、甲状腺超声、血清25-羟基维生素D、游离T3、游离T4、促甲状腺激素、钙、镁、磷、总蛋白、白蛋白、葡萄糖、肌酐水平及肾小球滤过率(GFR)。主要观察指标:血清25-羟基维生素D水平和甲状腺结节大小。样本量和特征:849人中，453人为甲状腺结节患者，396人为健康个体。结果:甲状腺结节患者的平均血清维生素D水平显著低于对照组(P< 0.001)。血清维生素D水平、血清总蛋白水平和eGFR是与甲状腺结节存在相关的独立变量(P< 0.05)。001, p =。005, P=。017年,分别)。结论:维生素D缺乏可能是甲状腺结节发生的病理生理因素之一。局限性:单中心和可能的信息偏倚。利益冲突:无。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Saudi Medicine 医学-医学：内科

CiteScore

2.80

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Annals of Saudi Medicine (ASM) is published bimonthly by King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. We publish scientific reports of clinical interest in English. All submissions are subject to peer review by the editorial board and by reviewers in appropriate specialties. The journal will consider for publication manuscripts from any part of the world, but particularly reports that would be of interest to readers in the Middle East or other parts of Asia and Africa. Please go to the Author Resource Center for additional information.