Correlation of CCL18 with Levels of Adi-pokines in the Sera of Patients with Myocardial Infarction in a 6-Month Period: Case Series

Abstract

Background: Myocardial Infarction (MI) is accompanied by inflammation and production of soluble inflammatory factors. The aim of this study was to investigate the correlation of CCL18 and CCL5 levels with those of resistin, adipsin, adiponectin and leptin adipokines in the sera of patients after MI. Materials and Methods: The correlations between levels of chemokines and adipokines were investigated in 36 patients in a 6-month follow-up after MI. For each patient, the measurements were done in 3 time points T0 (first 12 hrs), T5 (fifth day of admission) and T180 (after 6 months). The clinical and demographical criteria of patients at the time of admission were also recorded. Results: The serum levels of CCL18 at T0 were significantly correlated with resistin levels at T180. Therefore, higher CCL18 levels at T0 were associated with higher resistin levels at T180 (r=0.413, P=0.017). Moreover, serum levels of CCL18 at T180 were significantly correlated with adipsin levels at T5. Therefore, higher adipsin levels at T5 were associated with higher CCL18 levels at T180 (r=0.213, P=0.001). Multivariate logistic regression showed that the left ventricular ejection fraction at T0 correlated with the covariant effect of adipsin T5 and CCL18 at T180 (P=0.029). Conclusion: This study showed the correlation between CCL18 and resistin levels and the effect of CCL18 on the long term production of resistin in the body. With the notion that worse prognosis is associated with higher long-term CCL18; it is possible to take advantage of the correlation between adipsin on day 5 and the increase in CCL18 as prognostic biomarkers on the first days after MI.