Prognostic Importance of Ki-67 in Breast Cancer and Its Relationship with Other Prognostic Factors.

G. Kanyilmaz, B. Yavuz, M. Aktan, M. Karaağaç, M. Uyar, S. Fındık
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引用次数: 42

Abstract

Objective The clinical feature of breast cancer is very heterogeneous because of the variable prognostic factors impact its behaviour. The aim of study is to find the prognostic importance of Ki-67 and to analyse the correlation between Ki-67 index and the other conventional prognostic factors in breast cancer patients. Materials and Methods Between 2010 and 2017, patients with invasive ductal carcinoma who received radiotherapy after surgery were included in study. A single pathologist re-defined of all cases retrospectively. Ki-67 were established three categories based on Ki-67 levels: low (<10%), intermediate (10-25%) and high (>25%). Results A total of 258 patients were included. 46 of 258 (18%) patients were in low, 82 of 258 (32%) patients were in intermediate and 130 of 258 (50%) patients were in high Ki-67 group. There were no correlations between menopausal status, age, and Ki-67 level. Low-pT stages tended to have low Ki-67 expression (p=0.07). Low-pN stages correlated with low Ki-67 values (p=0.007). Patients with ECE (+) were prone to have higher Ki-67 values (p=0.02). The significant correlation was seen between Ki-67 and tumour grading (p=<0.0001). Patients with LVI (+) had higher Ki-67 expression (p=0.007). Luminal A tumours were correlated with low Ki-67 group (p=<0.0001). Ki-67 values had significant effect on DFS (p=0.03) but not OS (p=0.09). Conclusion This study showed that high Ki-67 expression is associated with higher pT-stage, higher pN-stage, higher grade, ER/PR negativity, HER2/neu positivity, ECE and LVI positivity. The prognostic impact of Ki-67 was only demonstrated for DFS.
Ki-67在乳腺癌预后中的重要性及其与其他预后因素的关系。
目的乳腺癌的临床特征具有异质性,影响其预后的因素多种多样。本研究旨在发现Ki-67在乳腺癌患者预后中的重要性,并分析Ki-67指数与其他常规预后因素的相关性。材料与方法2010 - 2017年浸润性导管癌术后放疗患者纳入研究。一位病理学家对所有病例进行回顾性重新定义。Ki-67根据Ki-67水平分为低(25%)三类。结果共纳入258例患者。258例患者中46例(18%)为低Ki-67组,82例(32%)为中Ki-67组,130例(50%)为高Ki-67组。绝经状态、年龄与Ki-67水平无相关性。低pt期Ki-67表达较低(p=0.07)。低pn分期与低Ki-67值相关(p=0.007)。ECE(+)患者Ki-67值较高(p=0.02)。Ki-67与肿瘤分级有显著相关性(p=<0.0001)。LVI(+)患者Ki-67表达较高(p=0.007)。腔内A肿瘤与低Ki-67组相关(p=<0.0001)。Ki-67值对DFS有显著影响(p=0.03),对OS无显著影响(p=0.09)。结论Ki-67高表达与高pt分期、高pn分期、高分级、ER/PR阴性、HER2/neu阳性、ECE和LVI阳性相关。Ki-67仅对DFS有预后影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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