Efficacy of gabapentin in the treatment of trigeminal neuralgia: A systematic review of randomized controlled trials

Q1 Medicine

Journal of Investigative and Clinical Dentistry Pub Date : 2019-08-11 DOI:10.1111/jicd.12448

Patrick Chieu Poa Ta, Hue Quyen Dinh, Kim Nguyen, Samuel Lin, Yong Li Ong, Anura Ariyawardana

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引用次数: 6

Abstract

The aim of this systematic review was to determine the efficacy of gabapentin (GBP) in the treatment of pain of idiopathic trigeminal neuralgia (TN). A comprehensive literature search was conducted using the Cumulative Index of Nursing and Allied Health Literature (EBSCO Industries), Emcare (Ovid), Medline (Ovid), Medline (PubMed), Scopus (Elsevier) and Web of Science (Clarivate Analytics). The inclusion criteria comprised randomized controlled trials of GBP as a monotherapy in the treatment of idiopathic TN in adult participants and publications in English. All other study methodologies were excluded. The search yielded 1472 articles, and after exclusion, 11 full-text articles were eligible for full-text analysis. Only two studies met the inclusion criteria. There is insufficient evidence either to support or refute the efficacy of GBP in the management of idiopathic TN. Therefore, further well-designed placebo-controlled trials are required to confirm the efficacy of GBP in managing TN pain as a single therapy.

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加巴喷丁治疗三叉神经痛的疗效：随机对照试验的系统评价。

本系统综述的目的是确定加巴喷丁(GBP)治疗特发性三叉神经痛(TN)疼痛的疗效。使用护理和联合健康文献累积索引(EBSCO Industries)、Emcare (Ovid)、Medline (Ovid)、Medline (PubMed)、Scopus(爱思唯尔)和Web of Science (Clarivate Analytics)进行了全面的文献检索。纳入标准包括GBP作为成人特发性TN单药治疗的随机对照试验和英文出版物。所有其他研究方法均被排除在外。检索得到1472篇文章，排除后，有11篇全文文章符合全文分析的条件。只有两项研究符合纳入标准。没有足够的证据支持或反驳GBP治疗特发性TN的有效性。因此，需要进一步设计良好的安慰剂对照试验来证实GBP作为单一疗法治疗TN疼痛的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Investigative and Clinical Dentistry DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： Journal of Investigative and Clinical Dentistry (JICD) aims to publish quality, peer reviewed original research and topical reviews on all aspects of investigative and clinical dentistry and craniofacial research, including molecular studies related to oral health and disease. Although international in outlook, the Editor especially encourages papers from the Asia Pacific. The journal also aims to provide clinicians, scientists and students of dentistry with a knowledge transfer platform for rapid publication of reports through an international journal, which will be available free online until 2012. Its scope, therefore, is broad, inclusive and international, but with a particular focus on Asia Pacific. The Editor welcomes manuscripts in the following key thematic areas in oral and maxillofacial sciences: Community Dentistry and Oral Epidemiology, Conservative Dentistry, Dental Biomaterials, Dental Pedagogy, Endodontics and Traumatology, Implant Dentistry, Oral Biosciences, Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Microbiology, Orthodontics, Oral Radiology, Oral Rehabilitation, Paedodontics, Periodontology and Periodontal Medicine.