THERAPEUTIC TARGETING OF MOLECULAR PATHWAYS IN COLORECTAL CANCER.

Q3 Medicine

Experimental oncology Pub Date : 2022-05-01 DOI:10.32471/exp-oncology.2312-8852.vol-44-no-1.17455

Nur Ebru

引用次数: 0

Abstract

Mutations in tumor suppressor genes, cell signaling, and genes associated with DNA repair lead to onset of colorectal cancer (CRC). Even though most CRC patients get clinical benefits from conventional treatments such as chemotherapy and radiotherapy, treatment success is still not at the desired level despite recent advances in CRC treatments. Therefore, further elucidation of the molecular signaling pathways involved in CRC progression will allow developing targeted therapies. With the detection of signaling pathways that lead to cancer progression and development of the successful treatment methods targeting these pathways, the progression of the disease can be prevented. This review provides an overview of the therapeutic roles of potential molecular targets in recent preclinical and clinical studies in CRC treatment.

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结直肠癌分子通路的靶向治疗。

肿瘤抑制基因、细胞信号和与DNA修复相关的基因的突变导致结直肠癌癌症（CRC）的发病。尽管大多数CRC患者从化疗和放疗等常规治疗中获得了临床益处，但尽管CRC治疗取得了最新进展，但治疗成功率仍未达到预期水平。因此，进一步阐明参与CRC进展的分子信号通路将有助于开发靶向疗法。通过检测导致癌症进展的信号通路，并开发针对这些通路的成功治疗方法，可以预防疾病的进展。这篇综述概述了潜在分子靶点在CRC治疗的近期临床前和临床研究中的治疗作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental oncology Medicine-Oncology

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The Experimental Oncology is an English-language journal that publishes review articles, original contributions, short communications, case reports and technical advances presenting new data in the field of experimental and fundamental oncology. Manuscripts should be written in English, contain original work, which has not been published or submitted for publication elsewhere. It also implies the transfer of the Copyright from the author to “Experimental Oncology”. No part of journal publications may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the prior permission of the publisher.