Takotsubo Syndrome

Gheorghe Andronic, Oana-Petronela Oancea, A. Costache, O. Mitu, F. Mitu
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Abstract

Abstract Takotsubo syndrome occurs in 1-2% of patients admitted in the emergency department with suspicion of ST-segment elevation myocardial infarction (STEMI), over 90% being postmenopause women. Psycho-emotional or physical stress is the main trigger that causes the release of catecholamines, with an important role in the pathophysiology of Takotsubo cardiomyopathy. In most cases, supportive and symptomatic treatment is sufficient, with a dynamic follow-up of the left ventricular (LV) function. Usually, a complete recovery occurs in 3-4 weeks. We are presenting the case of a 67-year-old patient with a severe angina attack which occuredafter a major psycho-emotional stress, with an electrocardiographic appearance of an anterior STEMI and echocardiographic apical ballooning, both compatible with Takotsubo syndrome. Coronary angiography showed a muscle bridge with a systolic compression of 75% on the anterior descending artery (ADA). The evolution was marked by the occurrence of cardiogenic shock remitted under treatment, with complete recovery of LV systolic function. The particularity of the case resides in an acute coronary syndrome (ACS) after a psycho-emotional stress associated with a muscular bridge, as well as the appearance of the cardiogenic shock.
摘要Takotsubo综合征发生在1-2%的怀疑ST段抬高型心肌梗死(STEMI)的急诊科患者中,超过90%的患者是绝经后妇女。心理、情绪或身体压力是导致儿茶酚胺释放的主要诱因,在Takotsubo心肌病的病理生理学中起着重要作用。在大多数情况下,支持性和症状性治疗就足够了,并对左心室(LV)功能进行动态随访。通常情况下,完全康复会在3-4周内发生。我们报告了一例67岁的严重心绞痛发作患者,该患者发生在严重的心理-情绪压力后,心电图表现为前部STEMI和超声心动图心尖气球状突起,两者均与Takotsubo综合征兼容。冠状动脉造影显示,前降动脉(ADA)有一个收缩压为75%的肌肉桥。这一演变的标志是发生心源性休克,在治疗后缓解,左心室收缩功能完全恢复。该病例的特殊性在于急性冠状动脉综合征(ACS),该综合征是在与肌肉桥相关的心理-情绪压力以及心源性休克的出现之后发生的。
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