The emergence of neoadjuvant therapy in advanced melanoma

IF 1 Q4 ONCOLOGY

Melanoma Management Pub Date : 2019-10-18 DOI:10.2217/mmt-2019-0007

James X. Sun, Dennis Kirichenko, J. Zager, Z. Eroglu

引用次数: 13

Abstract

The discovery of immunotherapy and targeted therapy has introduced new and effective treatment options for advanced melanoma, providing therapeutic options where none existed before. The natural extension of these novel therapies is to identify their role in the neoadjuvant setting. Neoadjuvant therapy for advanced melanoma is still in its infancy, with a wealth of clinical trials underway. Early results are promising, allowing for management of a disease that previously had few options. We review the current literature and interim results from several ongoing investigations to understand the current state of neoadjuvant treatment options and what is to come. These studies pave the way for further advancements in melanoma therapy.

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晚期黑色素瘤新辅助治疗的出现

免疫疗法和靶向治疗的发现为晚期黑色素瘤提供了新的有效治疗方案，提供了以前没有的治疗方案。这些新疗法的自然延伸是确定它们在新佐剂环境中的作用。晚期黑色素瘤的新辅助治疗仍处于起步阶段，大量临床试验正在进行中。早期的结果是有希望的，允许管理以前几乎没有选择的疾病。我们回顾了目前的文献和几项正在进行的研究的中期结果，以了解新辅助治疗方案的现状和未来的发展。这些研究为黑色素瘤治疗的进一步发展铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Melanoma Management ONCOLOGY-

CiteScore

5.10

自引率

0.00%

发文量

审稿时长

13 weeks

期刊介绍： Skin cancer is on the rise. According to the World Health Organization, 132,000 melanoma skin cancers occur globally each year. While early-stage melanoma is usually relatively easy to treat, once disease spreads prognosis worsens considerably. Therefore, research into combating advanced-stage melanoma is a high priority. New and emerging therapies, such as monoclonal antibodies, B-RAF and KIT inhibitors, antiangiogenic agents and novel chemotherapy approaches hold promise for prolonging survival, but the search for a cure is ongoing. Melanoma Management publishes high-quality peer-reviewed articles on all aspects of melanoma, from prevention to diagnosis and from treatment of early-stage disease to late-stage melanoma and metastasis. The journal presents the latest research findings in melanoma research and treatment, together with authoritative reviews, cutting-edge editorials and perspectives that highlight hot topics and controversy in the field. Independent drug evaluations assess newly approved medications and their role in clinical practice. Key topics covered include: Risk factors, prevention and sun safety education Diagnosis, staging and grading Surgical excision of melanoma lesions Sentinel lymph node biopsy Biological therapies, including immunotherapy and vaccination Novel chemotherapy options Treatment of metastasis Prevention of recurrence Patient care and quality of life.