Endocrine gland-derived vascular endothelial growth factor and placenta-mediated pregnancy complication

Q4 Medicine

中华围产医学杂志 Pub Date : 2019-10-16 DOI:10.3760/CMA.J.ISSN.1007-9408.2019.10.009

Chanjuan Zeng, Weishe Zhang

引用次数: 0

Abstract

Placenta-mediated pregnancy complication (PMPC), including preeclampsia, fetal growth restriction and recurrent pregnancy loss, is caused by inadequate trophoblast invasion and abnormal remodeling of maternal spiral arteries in early pregnancy, resulting in adverse perinatal outcomes and affecting the long-term maternal and child health. However, the molecular mechanisms of PMPC remain unclear. Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is highly expressed in human placenta and plays an important role in the development of a normal placenta through promoting placental angiogenesis and inhibiting trophoblast migration and invasion. EG-VEGF dysregulation is closely related to the pathogenesis of PMPC. This review described recent advances in EG-VEGF for better understanding of the underlying mechanism of PMPC and providing a potential biomarker for early diagnosis of PMPC. Key words: Pregnancy complications; Placenta diseases; Vascular endothelial growth factor, endocrine-gland-derived

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内分泌腺衍生血管内皮生长因子与胎盘介导的妊娠并发症

胎盘介导的妊娠并发症（PMPC），包括先兆子痫、胎儿生长受限和复发性妊娠损失，是由妊娠早期滋养层侵袭不足和母体螺旋动脉异常重塑引起的，导致不良围产期结局，影响长期母婴健康。然而，PMPC的分子机制尚不清楚。内分泌腺衍生的血管内皮生长因子（EG-VEGF）在人类胎盘中高度表达，通过促进胎盘血管生成和抑制滋养层细胞迁移和侵袭，在正常胎盘的发育中发挥重要作用。EG-VEGF失调与PMPC的发病机制密切相关。这篇综述描述了EG-VEGF的最新进展，以更好地了解PMPC的潜在机制，并为PMPC的早期诊断提供潜在的生物标志物。关键词：妊娠并发症；胎盘疾病；血管内皮生长因子，内分泌腺来源

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来源期刊

中华围产医学杂志 Medicine-Obstetrics and Gynecology

CiteScore

0.70

自引率

0.00%

发文量

4446

期刊介绍： Chinese Journal of Perinatal Medicine was founded in May 1998. It is one of the journals of the Chinese Medical Association, which is supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by Peking University First Hospital. Perinatal medicine is a new discipline jointly studied by obstetrics and neonatology. The purpose of this journal is to "prenatal and postnatal care, improve the quality of the newborn population, and ensure the safety and health of mothers and infants". It reflects the new theories, new technologies, and new progress in perinatal medicine in related disciplines such as basic, clinical and preventive medicine, genetics, and sociology. It aims to provide a window and platform for academic exchanges, information transmission, and understanding of the development trends of domestic and foreign perinatal medicine for the majority of perinatal medicine workers in my country.