The role of epigenetics in hypothalamic energy balance control: implications for obesity

IF 4.1 Q2 CELL BIOLOGY
A. Obri, M. Claret
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引用次数: 19

Abstract

Despite enormous social and scientific efforts, obesity rates continue to increase worldwide. While genetic factors contribute to obesity development, genetics alone cannot explain the current epidemic. Obesity is essentially the consequence of complex genetic-environmental interactions. Evidence suggests that contemporary lifestyles trigger epigenetic changes, which can dysregulate energy balance and thus contribute to obesity. The hypothalamus plays a pivotal role in the regulation of body weight, through a sophisticated network of neuronal systems. Alterations in the activity of these neuronal pathways have been implicated in the pathophysiology of obesity. Here, we review the current knowledge on the central control of energy balance with a focus on recent studies linking epigenetic mechanisms in the hypothalamus to the development of obesity and metabolic disorders.
表观遗传学在下丘脑能量平衡控制中的作用:对肥胖的影响
尽管做出了巨大的社会和科学努力,全世界的肥胖率仍在继续上升。虽然遗传因素有助于肥胖的发展,但仅靠遗传学并不能解释目前的流行。肥胖本质上是复杂的遗传环境相互作用的结果。有证据表明,当代生活方式会引发表观遗传学变化,从而失调能量平衡,从而导致肥胖。下丘脑通过复杂的神经元系统网络在调节体重方面发挥着关键作用。这些神经元通路活性的改变与肥胖的病理生理学有关。在这里,我们回顾了目前关于能量平衡中央控制的知识,重点是最近将下丘脑的表观遗传学机制与肥胖和代谢紊乱的发展联系起来的研究。
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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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