Developing FRET Networks for Sensing.

IF 5.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Annual Review of Analytical Chemistry Pub Date : 2022-02-17 DOI:10.1146/annurev-anchem-061020-014925

W. R. Algar, Katherine D. Krause

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引用次数: 9

Abstract

Förster resonance energy transfer (FRET) is a widely used fluorescence-based sensing mechanism. To date, most implementations of FRET sensors have relied on a discrete donor-acceptor pair for detection of each analytical target. FRET networks are an emerging concept in which target recognition perturbs a set of interconnected FRET pathways between multiple emitters. Here, we review the energy transfer topologies and scaffold materials for FRET networks, propose a general nomenclature, and qualitatively summarize the dynamics of the competitive, sequential, homoFRET, and heteroFRET pathways that constitute FRET networks. Implementations of FRET networks for sensing are also described, including concentric FRET probes, other single-vector multiplexing, and logic gates and switches. Unresolved questions and future research directions for current systems are discussed, as are potential but currently unexplored applications of FRET networks in sensing. Expected final online publication date for the Annual Review of Analytical Chemistry Volume 15 is June 2022. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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开发FRET网络传感。

Förster共振能量转移（FRET）是一种广泛使用的基于荧光的传感机制。迄今为止，FRET传感器的大多数实施方式都依赖于离散的供体-受体对来检测每个分析靶标。FRET网络是一个新兴的概念，其中目标识别干扰多个发射器之间的一组互连FRET通路。在这里，我们回顾了FRET网络的能量转移拓扑结构和支架材料，提出了一个通用的命名法，并定性地总结了构成FRET网络中竞争性、顺序性、同源性和异质性FRET途径的动力学。还描述了用于感测的FRET网络的实现，包括同心FRET探针、其他单矢量复用以及逻辑门和开关。讨论了当前系统尚未解决的问题和未来的研究方向，以及FRET网络在传感中的潜在但目前尚未探索的应用。《分析化学年度评论》第15卷预计最终在线出版日期为2022年6月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annual Review of Analytical Chemistry CHEMISTRY, ANALYTICAL-SPECTROSCOPY

CiteScore

14.80

自引率

1.20%

发文量

期刊介绍： The Annual Review of Analytical Chemistry, launched in 2008, offers a comprehensive perspective on the field, drawing from diverse disciplines such as biology, physics, and engineering, with analytical chemistry as the central theme. The journal's current volume has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license.