Atopy and Allergic Diseases Have No Impact on the Severity of COVID-19

IF 0.3 Q4 ALLERGY

Astim Allerji Immunoloji Pub Date : 2021-12-22 DOI:10.21911/aai.676

A. Can, Deniz Eyice Karabacak, C. Tüzer, Alpay Medet ALİBEYOĞLU2, Murat Köse, S. Demir, S. Büyüköztürk, B. Çolakoğlu, A. Gelincik

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Abstract

Objective: The clinical features of COVID-19 range from asymptomatic disease to severe pneumonia or even death. Therefore, many researchers have investigated the factors that could affect the severity of COVID-19. We aimed to assess the impact of aero-allergen sensitization and allergic diseases on the severity of COVID-19. Materials and Methods: We included 60 adult patients with symptomatic COVID-19 and allocated them into two groups equal in number as having severe and non-severe COVID-19. We evaluated the demographic features and allergic diseases in addition to clinical, laboratory and radiological findings of COVID-19. Skin prick tests (SPTs) with common aero-allergens, serum total IgE levels and blood eosinophil counts were evaluated 3 months after the patient’s recovery from COVID-19.Results: The mean age of the patients was 52 ± 11 years and 73.3% of the patients were male. There was no significant difference between the two groups in terms of age, gender, smoking habits, obesity and comorbidities. Although the frequency of sensitization to aero-allergens and the allergic diseases were similar, the history of allergic diseases in the family was higher in the severe group (p<0.001). The polysensitization in SPTs was associated with the presence of a cytokine storm during the infection (p=0.02). Total IgE levels and blood eosinophil counts were not significantly different between the two groups.Conclusion: The presence of atopy or allergic diseases does not seem to be related to the severity of COVID-19. However, polysensitization and a family history of allergic diseases are more prominent in those having a cytokine storm and severe COVID-19, respectively. Keywords: COVID-19, atopy, allergic disease, aero-allergen sensitization, cytokine storm

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变态反应性疾病对新冠肺炎的严重程度没有影响

目的:COVID-19的临床特征从无症状疾病到严重肺炎甚至死亡。因此，许多研究人员研究了可能影响COVID-19严重程度的因素。我们的目的是评估航空过敏原致敏和过敏性疾病对COVID-19严重程度的影响。材料和方法:我们纳入60例有症状的成年COVID-19患者，将其分为重症和非重症两组。我们评估了COVID-19的人口统计学特征和过敏性疾病，以及临床、实验室和放射学结果。在患者COVID-19康复后3个月，评估皮肤点刺试验(SPTs)中常见空气过敏原、血清总IgE水平和血嗜酸性粒细胞计数。结果:患者平均年龄52±11岁，男性占73.3%。两组在年龄、性别、吸烟习惯、肥胖和合并症方面无显著差异。虽然航空过敏原致敏频率与变应性疾病发生率相似，但严重组变应性疾病家族史较高(p<0.001)。spt的多致敏与感染期间细胞因子风暴的存在有关(p=0.02)。两组总IgE水平和血嗜酸性粒细胞计数无显著差异。结论:特应性或过敏性疾病的存在似乎与COVID-19的严重程度无关。然而，多致敏和过敏性疾病家族史分别在细胞因子风暴和严重COVID-19患者中更为突出。关键词:COVID-19，特应性，变应性疾病，航空过敏原致敏，细胞因子风暴

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Astim Allerji Immunoloji ALLERGY-

CiteScore

0.80

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0.00%

发文量

期刊介绍： Asthma Allergy Immunology has been published three times a year in April, August and December as the official and periodical journal of the Turkish National Society of Allergy and Clinical Immunology since 2003. All articles published in the journal have been available online since 2003. A peer reviewed system is used in evaluation of the manuscripts submitted to Asthma Allergy Immunology. The official language of the journal is English. The aim of the journal is to present advances in the field of allergic diseases and clinical immunology to the readers. In accordance with this goal, manuscripts in the format of original research, review, case report, articles about clinical and practical applications and editorials, short report and letters to the editor about allergic diseases and clinical immunology are published in the journal. The target reader population of the Asthma Allergy Immunology includes specialists and residents of allergy and clinical immunology, pulmonology, internal medicine, pediatrics, dermatology and otolaryngology as well as physicians working in other fields of medicine interested in allergy and immunological diseases.