Cognitive Processing Therapy Versus Medication for the Treatment of Comorbid Substance Use Disorder and Post-Traumatic Stress Disorder in Egyptian patients (Randomized Clinical Trial)

IF 0.8 4区 心理学 Q4 PSYCHOLOGY, CLINICAL
Amani ElBarazi, O. Badary, M. Elmazar, H. Elrassas
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引用次数: 1

Abstract

"Earlier research has established that posttraumatic stress disorder (PTSD) and substance use disorder (SUD) frequently coexist. Aims: Cognitive Processing Therapy was compared to Sertraline and a placebo in an RCT for treating patients with comorbid SUD and PTSD. Methods: 150 patients with SUD and PTSD were interviewed by clinicians and asked to fill out the Clinician-Administered PTSD Scale (CAPS-5), Posttraumatic Stress Disorder Checklist (PCL-5), Beck Depression Inventory (BDI-II), Timeline Follow Back Interview (TLFB), and Brief Addiction Monitor (BAM). Patients were randomly assigned to the following conditions: CPT (n=50), Sertraline (n=50), or Placebo (n=50). Pretreatment, posttreatment, six and, twelve-month follow-up assessments were conducted. Results: When compared to the sertraline group, CPT resulted in much higher reductions in CAPS scores at posttreatment assessment (d=0.93, p < .000). When compared to the control group, CPT considerably reduced PTSD symptoms (the effect size, d=1.9, p < .000). Sertraline resulted in many significant decreases in CAPS when compared to control groups (the effect size , d=1.11, p<.000). At posttreatment, SUD and depression severity were significantly reduced in both CPT and Sertraline groups. After six and twelve months of follow-up, these differences persisted. Conclusion: Comparatively to the control group, CPT and Sertraline significantly decreased PTSD, SUD, and depression."
认知加工疗法与药物治疗埃及患者合并物质使用障碍和创伤后应激障碍(随机临床试验)
“早期的研究已经证实,创伤后应激障碍(PTSD)和物质使用障碍(SUD)经常共存。目的:在随机对照试验中,将认知处理疗法与舍曲林和安慰剂进行比较,以治疗合并有SUD和PTSD的患者(CAPS-5)、创伤后应激障碍检查表(PCL-5)、贝克抑郁量表(BDI-II)、时间线随访访谈(TLFB)和简短成瘾监测(BAM)。患者被随机分配到以下条件:CPT(n=50)、舍曲林(n=5 0)或安慰剂(n=1 0)。进行了治疗前、治疗后、6个月和12个月的随访评估。结果:与舍曲林组相比,CPT在治疗后评估中导致CAPS评分的降低要高得多(d=0.93,p<.000)。与对照组相比,CPT显著降低了PTSD症状(效应大小,d=1.9,p<.000)。与对照组相比,舍曲林导致CAPS显著降低(效应大小(d=1.11,p<0.000)。治疗后,CPT和舍曲林组的SUD和抑郁严重程度均显著降低。经过6个月和12个月的随访,这些差异仍然存在。结论:与对照组相比,CPT和舍曲林能显著降低PTSD、SUD和抑郁。“
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
20
期刊介绍: The journal is devoted to the advancement of the clinical theory and practice of evidence-based psychotherapies (EBP) (e.g., evidence-based psychological assessments, evidence-based psychological treatments). The journal publishes original papers dealing with EBP and psychology, psychiatry, the medical and mental specialties, and allied areas of science.
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