Synthesis of 5-Aroyl-2-aryl-3-hydroxypyridin-4(1H)-ones

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-06-10 DOI:10.3390/m1668

Elena V. Steparuk, D. L. Obydennov, V. Sosnovskikh

引用次数: 0

Abstract

A two-stage synthesis of 5-aroyl-2-aryl-3-hydroxypyridin-4(1H)-ones (56–66% overall yields) was carried out by refluxing 5-aroyl-3-(benzyloxy)-2-(het)aryl-4H-pyran-4-ones with ammonium acetate in AcOH and subsequent debenzylation. The prepared N-unsubstituted 4-pyridones exist in the pyridone tautomeric form.

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5-芳基-2-芳基-3-羟基吡啶-4(1H)-酮的合成

用乙酸铵在AcOH中回流5-芳基-3-(苯氧基)-2-(戊基)芳基- 4h -吡喃-4- 1，进行了2段合成5-芳基-2-芳基-3-羟基吡啶-4(1H)- 1(总产率为56-66%)。所制备的n -未取代4-吡啶酮以吡啶酮互变异构形式存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)