Antibacterial and Cytotoxic Compounds from Endophyte Fusarium solani isolated from Centella asiatica (L.)

IF 0.9 Q4 CHEMISTRY, MEDICINAL

Journal of Biologically Active Products from Nature Pub Date : 2022-09-03 DOI:10.1080/22311866.2022.2144947

F. Moni, Naki Saifullah, F. Afroz, S. Rony, S. Sharmin, A. Shahinuzzaman, M. A. Al-Mansur, S. M. Al-Reza, M. Sohrab

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Abstract

Abstract The antimicrobial and cytotoxic activity of metabolites isolated from an endophyte Fusarium solani were evaluated which was associated with the medicinal plant Centella asiatica Linn. Repeated chromatographic separations of ethyl acetate extract of Fusarium solani lead to the isolation of three naphthoquinone Anhydrofusarubin (1), Fusarubin (2), Javanicin (3) and one aza-anthraquinone 5-deoxybostrycoidin (4). The structures of isolated compounds were determined by analysis of NMR spectrum data and comparison of spectroscopic data with those of known compounds. The cytotoxic activity of isolated compounds was tested against the Human Lung cancer cell line and antimicrobial activity by disc diffusion method. Significant antibacterial activity and Cytotoxicity of the isolated secondary metabolites suggested that Azaanthraquinones and Napthaquinones are potential lead to develop antibacterial and anticancer drugs. GRAPHICAL ABSTRACT

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积雪草内生镰刀菌中的抗菌和细胞毒性化合物

摘要对从药用植物积雪草内生镰刀菌中分离的代谢产物的抗菌和细胞毒性进行了评价。通过对龙葵乙酸乙酯提取物的重复色谱分离，分离出三种萘醌-无水龙葵红素（1）、龙葵红蛋白（2）、爪哇红素（3）和一种氮杂蒽醌-5-脱氧博斯翠素（4）。通过分析NMR光谱数据并将光谱数据与已知化合物的光谱数据进行比较来确定分离的化合物的结构。用圆盘扩散法检测分离的化合物对人癌症细胞株的细胞毒性和抗菌活性。分离的次级代谢产物具有显著的抗菌活性和细胞毒性，表明氮杂蒽醌和萘醌是开发抗菌和抗癌药物的潜在先导物。图形摘要

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来源期刊

Journal of Biologically Active Products from Nature Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)

CiteScore

2.10

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0.00%

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