Influence of antibody dependent enhancement (ADE) on vaccine development/ 抗体依赖性增强作用对疫苗研发的影响

Abstract

Antibody dependent enhancement (ADE) is a common phenomenon in virology. It is involved in the mechanisms of infections caused by Dengue virus (DV), severe acute respiratory syndrome coronavirus (SARS-CoV), influenza virus, HIV and other viruses and affects the research and development of vaccines against them. Because the pre-existing specific antibodies or antibodies at sub-neutralizing titer can enhance the infectivity of viruses, leading to disease aggravation, vaccination may promote infection instead of preventing it. This article focused on the impact of ADE on the research and development of vaccines and the assessment of ADE.