Endothelial dysfunction: developmental mechanisms and therapeutic strategies

Q3 Pharmacology, Toxicology and Pharmaceutics
Dmitry V. Shcheblykin, Anton A. Bolgov, M. Pokrovskii, Julia V. Stepenko, Julia M. Tsuverkalova, Olesya V. Shcheblykina, P. A. Golubinskaya, L. Korokina
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引用次数: 1

Abstract

Introduction: Every year the importance of the normal functioning of the endothelial layer of the vascular wall in maintaining the health of the body becomes more and more obvious. The physiological role of the endothelium: The endothelium is a metabolically active organ actively involved in the regulation of hemostasis, modulation of inflammation, maintenance of hemovascular homeostasis, regulation of angiogenesis, vascular tone, and permeability. Risk factors for the development of endothelial dysfunction: Currently, insufficient bioavailability of nitric oxide is considered the most significant risk factor for endothelial dysfunction. Mechanisms of development of endothelial dysfunction: The genesis of endothelial dysfunction is a multifactorial process. Among various complex mechanisms, this review examines oxidative stress, inflammation, hyperglycemia, vitamin D deficiency, dyslipidemia, excess visceral fat, hyperhomocysteinemia, hyperuricemia, as well as primary genetic defect of endotheliocytes, as the most common causes in the population underlying the development of endothelial dysfunction. Markers of endothelial dysfunction in various diseases: This article discusses the main biomarkers of endothelial dysfunction currently used, as well as promising biomarkers in the future for laboratory diagnosis of this pathology. Therapeutic strategies: Therapeutic approaches to the endothelium in order to prevent or reduce a degree of damage to the vascular wall are briefly described. Conclusion: Endothelial dysfunction is a typical pathological process involved in the pathogenesis of many diseases. Thus, pharmacological agents with endothelioprotective properties can provide more therapeutic benefits than a drug without such an effect.
Endothelial功能障碍:发育机制和治疗策略
引言:血管壁内皮层的正常功能在维持身体健康方面的重要性每年都变得越来越明显。内皮的生理作用:内皮是一种代谢活跃的器官,积极参与止血、炎症调节、血管稳态维持、血管生成、血管张力和通透性的调节。内皮功能障碍的危险因素:目前,一氧化氮的生物利用度不足被认为是内皮功能障碍的最重要危险因素。内皮功能障碍的发展机制:内皮功能障碍的发生是一个多因素的过程。在各种复杂的机制中,这篇综述探讨了氧化应激、炎症、高血糖、维生素D缺乏、血脂异常、内脏脂肪过多、高同型半胱氨酸血症、高尿酸血症以及内皮细胞的原发性遗传缺陷,这些是内皮功能障碍发展的最常见原因。各种疾病中内皮功能障碍的标志物:本文讨论了目前使用的内皮功能障碍的主要标志物,以及未来用于该病理学实验室诊断的有前景的标志物。治疗策略:为了预防或减少一定程度的血管壁损伤,对内皮细胞的治疗方法进行了简要描述。结论:内皮功能障碍是一个典型的病理过程,参与了多种疾病的发病机制。因此,与没有内皮保护作用的药物相比,具有内皮保护特性的药物可以提供更多的治疗益处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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