Plasma NfL is associated with mild cognitive decline in patients with diabetes

IF 1.7 4区医学 Q3 GERIATRICS & GERONTOLOGY

Psychogeriatrics Pub Date : 2022-03-13 DOI:10.1111/psyg.12819

Noriko Marutani, S. Akamine, D. Kanayama, S. Gotoh, K. Yanagida, Rikiya Maruyama, Kohji Mori, Tesshin Miyamoto, Hiroyoshi Adachi, Yukako Sakagami, K. Yoshiyama, Maki Hotta, Aki Nagase, J. Kozawa, N. Maeda, M. Otsuki, T. Matsuoka, H. Iwahashi, I. Shimomura, N. Murayama, Hiroshi Watanabe, Manabu Ikeda, I. Mizuta, Takashi Kudo

引用次数: 3

Abstract

Patients with diabetes are at a higher risk for cognitive decline. Thus, biomarkers that can provide early and simple detection of cognitive decline are required. Neurofilament light chain (NfL) is a cytoskeletal protein that constitutes neural axons. Plasma NfL levels are elevated when neurodegeneration occurs. Here, we investigated whether plasma NfL levels were associated with cognitive decline in patients with type 2 diabetes.

查看原文本刊更多论文

血浆NfL与糖尿病患者轻度认知能力下降有关

糖尿病患者认知能力下降的风险更高。因此，需要能够提供早期和简单检测认知能力下降的生物标志物。神经丝轻链(NfL)是构成神经轴突的细胞骨架蛋白。当神经退行性变发生时，血浆NfL水平升高。在这里，我们研究了血浆NfL水平是否与2型糖尿病患者的认知能力下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Psychogeriatrics Medicine-Geriatrics and Gerontology

CiteScore

3.60

自引率

5.00%

发文量

115

审稿时长

>12 weeks

期刊介绍： Psychogeriatrics is an international journal sponsored by the Japanese Psychogeriatric Society and publishes peer-reviewed original papers dealing with all aspects of psychogeriatrics and related fields The Journal encourages articles with gerontopsychiatric, neurobiological, genetic, diagnostic, social-psychiatric, health-political, psychological or psychotherapeutic content. Themes can be illuminated through basic science, clinical (human and animal) studies, case studies, epidemiological or humanistic research