A Case Series on GeneXpert Negative Tuberculous Mastitis and the Effect of Anti-tuberculous Treatment

Q4 Medicine

Journal of Communicable Diseases Pub Date : 2022-06-30 DOI:10.24321/0019.5138.202277

I. Ajmal

{"title":"A Case Series on GeneXpert Negative Tuberculous Mastitis and the Effect of Anti-tuberculous Treatment","authors":"I. Ajmal","doi":"10.24321/0019.5138.202277","DOIUrl":null,"url":null,"abstract":"Background: Breast tuberculosis is significant due to its rare occurrence and dilemma in prospective treatment and differentiation from neoplastic lesions. Tuberculosis of the breast usually affects women from Asia, most commonly, the Indian subcontinent and Africa. Tuberculous mastitis has a wide range of clinical presentation, radiological features, and even microbiological presentation. Materials and Method: A prospective study was conducted over 6 months. 40 female patients with varied presentations correlating to tuberculous mastitis with a lump in the breast for a particular period of time were included in the study. Results: The patients’ ages varied from 20 to 45 years. After routine investigations, the patients went in for incision and drainage or incisional biopsy or both and postoperatively their histopathological reports revealed granulomatous breast disease (tuberculous mastitis) with negative GeneXpert (CB-NAAT). Patients were started on an anti-tubercular treatment regimen and showed a progressive decrease in symptomatology. Conclusion: Granulomatous breast abscess/ tuberculous breast abscess has a varied presentation and no fixed treatment regime. Anti-tuberculous drugs in such patients proved to be efficacious in symptomatic relief with prevention of recurrence/ fistula formation.","PeriodicalId":35952,"journal":{"name":"Journal of Communicable Diseases","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Communicable Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.24321/0019.5138.202277","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Breast tuberculosis is significant due to its rare occurrence and dilemma in prospective treatment and differentiation from neoplastic lesions. Tuberculosis of the breast usually affects women from Asia, most commonly, the Indian subcontinent and Africa. Tuberculous mastitis has a wide range of clinical presentation, radiological features, and even microbiological presentation. Materials and Method: A prospective study was conducted over 6 months. 40 female patients with varied presentations correlating to tuberculous mastitis with a lump in the breast for a particular period of time were included in the study. Results: The patients’ ages varied from 20 to 45 years. After routine investigations, the patients went in for incision and drainage or incisional biopsy or both and postoperatively their histopathological reports revealed granulomatous breast disease (tuberculous mastitis) with negative GeneXpert (CB-NAAT). Patients were started on an anti-tubercular treatment regimen and showed a progressive decrease in symptomatology. Conclusion: Granulomatous breast abscess/ tuberculous breast abscess has a varied presentation and no fixed treatment regime. Anti-tuberculous drugs in such patients proved to be efficacious in symptomatic relief with prevention of recurrence/ fistula formation.

查看原文本刊更多论文

GeneXpert阴性结核性乳腺炎病例系列及抗结核治疗效果

背景：乳腺结核由于其罕见的发生率以及在前瞻性治疗和与肿瘤性病变的鉴别方面的困境而具有重要意义。乳腺结核通常影响亚洲女性，最常见的是印度次大陆和非洲。结核性乳腺炎有广泛的临床表现、放射学特征，甚至微生物表现。材料和方法：一项为期6个月的前瞻性研究。该研究包括40名女性患者，她们有不同的表现，与特定时期内乳房有肿块的结核性乳腺炎相关。结果：患者年龄在20～45岁之间。在常规检查后，患者进行了切口和引流或切口活检，或两者兼有，术后他们的组织病理学报告显示肉芽肿性乳腺病（结核性乳腺炎），GeneXpert（CB-NAAT）阴性。患者开始接受抗结核治疗方案，症状逐渐减轻。结论：肉芽肿性乳腺脓肿/结核性乳腺脓肿表现多样，无固定治疗方案。在这类患者中，抗结核药物被证明在症状缓解和预防复发/瘘管形成方面是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Communicable Diseases Medicine-Infectious Diseases

CiteScore

0.40

自引率

0.00%

发文量

期刊介绍： Journal of Communicable Diseases (E-ISSN: 0019-5138 & P-ISSN: 2394-7047) is published by ADR Publications and is the official publication of Indian Society of Malaria and Other Communicable Diseases. Journal of Communicable Diseases covers scientific researches in the field of communicable diseases. Accept articles with scientific excellence in the form of (1) Original articles in basic and field research (2) Critical reviews, (3) surveys, (4) Case studies, (5) opinions/Correspondence/letters to editor, etc. The first issue of the publication entitled “Bulletin of the National Society of India for Malaria and Other Mosquito-Borne Diseases” the precursor of “Journal of Communicable Disease” (J Commun Dis) was brought out in 1953. The objects and purposes of J Commun Dis are: • to advance knowledge regarding the cause, prevalence, epidemiology, treatment, prevention and control of malaria and other-mosquito-borne diseases and other communicable diseases, • to stimulate scientific and practical interest among individuals and organizations in the prompt and effective application of treatment and control methods, • to integrate scientific and field activities and co-ordinate various scientific investigations, • to disseminate such knowledge both to scientists and to the general public.