Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2020-01-02 DOI:10.1080/15376516.2019.1652872

M. Alavi, A. Shamsizadeh, G. Karimi, A. Roohbakhsh

{"title":"Transient receptor potential ankyrin 1 (TRPA1)-mediated toxicity: friend or foe?","authors":"M. Alavi, A. Shamsizadeh, G. Karimi, A. Roohbakhsh","doi":"10.1080/15376516.2019.1652872","DOIUrl":null,"url":null,"abstract":"Abstract Transient receptor potential (TRP) channels have been widely studied during the last decade. New studies uncover new features and potential applications for these channels. TRPA1 has a huge distribution all over the human body and has been reported to be involved in different physiological and pathological conditions including cold, pain, and damage sensation. Considering its role, many studies have been devoted to evaluating the role of this channel in the initiation and progression of different toxicities. Accordingly, we reviewed the most recent studies and divided the role of TRPA1 in toxicology into the following sections: neurotoxicity, cardiotoxicity, dermatotoxicity, and pulmonary toxicity. Acetaminophen, heavy metals, tear gases, various chemotherapeutic agents, acrolein, wood smoke particulate materials, particulate air pollution materials, diesel exhaust particles, cigarette smoke extracts, air born irritants, sulfur mustard, and plasticizers are selected compounds and materials with toxic effects that are, at least in part, mediated by TRPA1. Considering the high safety of TRPA1 antagonists and their efficacy to resolve selected toxic or adverse drug reactions, the future of these drugs looks promising.","PeriodicalId":49117,"journal":{"name":"Toxicology Mechanisms and Methods","volume":"30 1","pages":"1 - 18"},"PeriodicalIF":2.8000,"publicationDate":"2020-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/15376516.2019.1652872","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Toxicology Mechanisms and Methods","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15376516.2019.1652872","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}

引用次数: 9

Abstract

Abstract Transient receptor potential (TRP) channels have been widely studied during the last decade. New studies uncover new features and potential applications for these channels. TRPA1 has a huge distribution all over the human body and has been reported to be involved in different physiological and pathological conditions including cold, pain, and damage sensation. Considering its role, many studies have been devoted to evaluating the role of this channel in the initiation and progression of different toxicities. Accordingly, we reviewed the most recent studies and divided the role of TRPA1 in toxicology into the following sections: neurotoxicity, cardiotoxicity, dermatotoxicity, and pulmonary toxicity. Acetaminophen, heavy metals, tear gases, various chemotherapeutic agents, acrolein, wood smoke particulate materials, particulate air pollution materials, diesel exhaust particles, cigarette smoke extracts, air born irritants, sulfur mustard, and plasticizers are selected compounds and materials with toxic effects that are, at least in part, mediated by TRPA1. Considering the high safety of TRPA1 antagonists and their efficacy to resolve selected toxic or adverse drug reactions, the future of these drugs looks promising.

查看原文本刊更多论文

瞬时受体电位锚蛋白1 (TRPA1)介导的毒性:是敌是友?

摘要瞬态受体电位（TRP）通道在过去十年中得到了广泛的研究。新的研究揭示了这些渠道的新特点和潜在应用。TRPA1在人体内分布广泛，据报道与不同的生理和病理条件有关，包括寒冷、疼痛和损伤感。考虑到其作用，许多研究致力于评估该通道在不同毒性的起始和发展中的作用。因此，我们回顾了最近的研究，并将TRPA1在毒理学中的作用分为以下几个部分：神经毒性、心脏毒性、皮肤毒性和肺毒性。对乙酰氨基酚、重金属、催泪瓦斯、各种化学治疗剂、丙烯醛、木烟颗粒材料、颗粒空气污染材料、柴油废气颗粒、香烟烟雾提取物、空气中的刺激物、硫芥末和增塑剂是选定的具有毒性作用的化合物和材料，其至少部分由TRPA1介导。考虑到TRPA1拮抗剂的高安全性及其解决选定毒性或不良药物反应的疗效，这些药物的未来看起来很有希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.