Polyketides and Alkaloids from the Deep-Sea-Derived Fungus Aspergillus fumigatus CBC18132

Abstract

: The fungal strain Aspergillus fumigatus CBC18132, isolated from deep-sea sediment, was investigated for secondary metabolites. Fermentation on rice medium followed by chromatographic separation led to the isolation of three polyketides ( 1 − 3 ) and ten alkaloids ( 4 − 13 ). The structures were determined by analyses of spectroscopic data ( 1 H and 13 C NMR, and MS data). The absolute configuration of the anthraquinone-derivative trypacidin ( 1 ) was resolved for the first time by a combination of ECD and specific rotation calculation. The probable biogenetic relationships of compounds 1 − 3 were described. All isolated compounds were inactive toward the  -glucosidase at the initial concentration of 4 mM.