Review of mechanisms of genotoxic action of dibenzo[def,p]chrysene (formerly dibenzo[a,l]pyrene)

IF 3.3 4区医学 Q2 TOXICOLOGY

Toxin Reviews Pub Date : 2022-09-20 DOI:10.1080/15569543.2022.2124419

K. Kowalczyk, J. Roszak, Z. Sobańska, M. Stępnik

引用次数: 0

Abstract

Abstract Polycyclic aromatic hydrocarbons (PAHs) are a large group of organic compounds that have always been present in the environment. With the technological and civilization development, exposure to this class of compounds has considerably increased. Dibenzo[def,p]chrysene (DBC), formerly known as dibenzo[a,l]pyrene, is one of the most important and probably the most carcinogenic among all PAHs tested so far. Its carcinogenic and mutagenic effects on mammalian cell systems and animals have been documented, and hence it was classified as “possibly carcinogenic to humans.” This review presents the most important aspects of mechanisms of genotoxicity after exposure to DBC.

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二苯并[def,p]芘(原二苯并[a,l]芘)遗传毒性作用机制综述

摘要多环芳烃(PAHs)是一大类一直存在于环境中的有机化合物。随着科技和文明的发展，这类化合物的暴露量大大增加。二苯并[def,p]chrysene (DBC)，以前称为二苯并[a,l]芘，是迄今为止检测到的所有多环芳烃中最重要的，可能也是最致癌的一种。它对哺乳动物细胞系统和动物的致癌和诱变作用已被记录在案，因此被归类为“可能对人类致癌”。这篇综述介绍了暴露于DBC后遗传毒性机制的最重要方面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxin Reviews 医学-毒理学

CiteScore

6.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Toxin Reviews provides an international forum for publishing state-of-the-art reviews and guest-edited single topic special issues covering the multidisciplinary research in the area of toxins derived from animals, plants and microorganisms. Our aim is to publish reviews that are of broad interest and importance to the toxinology as well as other life science communities. Toxin Reviews aims to encourage scientists to highlight the contribution of toxins as research tools in deciphering molecular and cellular mechanisms, and as prototypes of therapeutic agents. Reviews should emphasize the role of toxins in enhancing our fundamental understanding of life sciences, protein chemistry, structural biology, pharmacology, clinical toxinology and evolution. Prominence will be given to reviews that propose new ideas or approaches and further the knowledge of toxinology.