Recurrent diffuse-type tenosynovial giant cell tumor of the left ankle: a case report

Abstract

Diffuse-type tenosynovial giant cell tumor (D-TGCT) is a rare, benign tumor. It is locally aggressive and prone to recurrence. Extensive synovectomy followed by low dose irradiation is the common therapy. Recently, “tumor landscaping” has been demonstrated to be involved in the etiology of this disease. In addition, new drugs have been developed to block the associated pathway. Here, we present a refractory case of D-TGCT over left ankle who received marginal excision followed by adjuvant radiotherapy. Disease relapse occurred 9 years later and he received repeat operation and adjuvant radiotherapy. After 30 months of follow-up, no disease progression or distant metastasis was observed.