The Prevalence of Asymptomatic Hyperuricemia in Patients with or Without Psoriatic Arthritis is Associated with a Similar Cardiovascular Risk

Q4 Medicine

Acta Medica Bulgarica Pub Date : 2022-10-01 DOI:10.2478/amb-2022-0024

R. Gancheva, T. Kundurzhiev, I. Sheitanov, T. Petranova, Z. Kolarov, P. Yankova, M. Nikolova, A. Kundurdzhiev

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引用次数: 0

Abstract

Abstract Aim: To investigate the association between cardiovascular burden and monosodium urate (MSU) deposits in the joints of patients with asymptomatic hyperuricemia and no evidence of arthritis and subjects with psoriatic arthritis and hyperuricemia. Patients and methods: A single-center, cross-sectional study including 52 individuals: 39 with asymptomatic hyperuricemia and 13 with psoriatic arthritis and hyperuricemia. All patients underwent ultrasound of the joints by which the presence or absence of MSU crystal deposits was assessed. Subjects underwent transthoracic echocardiography by which left ventricular mass index (LVMI) was estimated. Intima-media thickness (IMT) of the common carotid arteries was measured and the presence of atherosclerotic plaques was registered. Results: We found no difference in the distribution of cardiovascular risk factors between the two groups. Further, no difference in their distribution was found between those who were not treated and those who were treated with urate-lowering medications. The frequency of articular MSU deposits was similar between non-allopurinol-treated and allopurinol-treated individuals (p = 0.554). There was no difference in the frequency of articular deposits between benzbromarone recipients and non-recipients (p = 0.396). We observed no connection between articular MSU deposits and LVMI (p = 0.625), IMT (p = 0.117) and atherosclerotic plaques (p = 0.102). Among untreated and treated with urate-lowering drugs there was no difference in LVMI (p = 0.063), IMT (p = 0.975) and plaque distribution (p = 1.000). Conclusion: We can assume that in patients with asymptomatic hyperuricemia and no evidence of arthritis and in subjects with psoriatic arthritis and asymptomatic hyperuricemia, only the prescription of urate-lowering medications for reduction of urate load and cardiovascular risk is not sufficient.

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伴有或不伴有银屑病关节炎的患者无症状高尿酸血症的患病率与相似的心血管风险相关

摘要目的：研究无症状高尿酸血症患者和银屑病关节炎和高尿酸症患者关节中单钠尿酸盐（MSU）沉积与心血管负荷之间的关系。患者和方法：一项单中心横断面研究，包括52名患者：39名无症状高尿酸血症患者，13名银屑病关节炎和高尿酸症患者。所有患者均接受了关节超声检查，以评估MSU晶体沉积物的存在与否。受试者接受了经胸超声心动图检查，通过该检查评估左心室质量指数（LVMI）。测量颈总动脉的内膜-中膜厚度（IMT），并记录动脉粥样硬化斑块的存在。结果：我们发现两组心血管危险因素的分布没有差异。此外，未接受治疗的患者和接受降尿酸药物治疗的患者之间的分布没有差异。关节MSU沉积的频率在非别嘌呤醇治疗和别嘌呤醇处理的个体之间相似（p=0.554）。苯溴马隆受体和非受体之间的关节沉积频率没有差异（p=0.396）。我们观察到关节MSU沉积物与LVMI之间没有联系（p=0.625），IMT（p=0.117）和动脉粥样硬化斑块（p=0.102）。在未经治疗和用降尿酸药物治疗的患者中，LVMI（p=0.063）、IMT（p=0.975）和斑块分布（p=1.000）没有差异，只有降低尿酸盐药物的处方来减少尿酸盐负荷和心血管风险是不够的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Medica Bulgarica Medicine-Medicine (all)

CiteScore

0.30

自引率

0.00%

发文量

审稿时长

25 weeks

期刊介绍： About 30 years ago - in 1973, on the initiative of the Publishing House „Medicine and Physical Culture", namely its former director Mr. Traian Ivanov, the Ministry of Health set up and accepted to subsidize a new medical magazine that was to be published only in the English language and had to reflect the status and the achievements of the Bulgarian medical science. Thus the language barrier was overcome and stable relations were established with the international medical society, large libraries, and university centers. The famous internationally known scientist professor Assen A. Hadjiolov was elected edition-in-chief by the first editorial staff and the magazine was named Acta Medica Bulgarica.