COVID-19 detection: Comparison and accuracy of several diagnostic tests

Q3 Agricultural and Biological Sciences
Mati Ullah Dad Ullah, M. Ibrar, S. Khan, H. Ullah, N. Khan
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引用次数: 2

Abstract

The emergence of coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) has created a global alarming situation. Initially, diagnosis of the virus was conducted by a combination of different assays including; electron microscopy (EM), computed tomography (CT) scan and whole-genome sequencing. However, such time-consuming diagnosis has critically highlighted the need for a fast and specific testing approach for earlier detection. It is expected that the ongoing research advances and the continuing efforts for the fight against COVID-19 will soon bring a fruitful discovery in in vitro diagnostics techniques. Meanwhile, the efficiency and performance of any novel diagnostic approach should be censoriously analyzed before it comes into practice. The aims of this study were to evaluate and compare the different diagnostic tests recommended by the World Health Organization (WHO) for earlier detection of the novel SARS-CoV-2. We found that the Clustered regularly interspaced short palindromic sequence (CRISPR/Cas) detection has relatively higher efficiency, compared to all the other tests. Therefore from this report, we concluded that the discovery of CRISPR/Cas based in vitro diagnostics will minimize the time limit as well as the cost for COVID-19 detection.
COVID-19检测:几种诊断测试的比较和准确性
由严重急性呼吸综合征冠状病毒(SARS-CoV-2)引起的2019冠状病毒病(COVID-19)大流行的出现,在全球造成了令人担忧的局面。最初,该病毒的诊断是通过不同检测方法的组合进行的,包括;电子显微镜(EM)、计算机断层扫描(CT)和全基因组测序。然而,这种耗时的诊断严重强调了需要一种快速和特定的早期检测方法。预计,随着研究的不断进展和抗击COVID-19的持续努力,体外诊断技术将很快取得丰硕成果。同时,任何新的诊断方法在付诸实践之前,都应该仔细分析其效率和性能。本研究的目的是评估和比较世界卫生组织(WHO)推荐的用于早期发现新型SARS-CoV-2的不同诊断检测方法。我们发现,与所有其他测试相比,聚类规则间隔短回文序列(CRISPR/Cas)检测具有相对较高的效率。因此,从本报告中,我们得出结论,基于体外诊断的CRISPR/Cas的发现将最大限度地减少COVID-19检测的时间限制和成本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.40
自引率
0.00%
发文量
16
审稿时长
4 weeks
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