Association of a genetic variant in chromosome 9p21 with increased risk of developing cervical cancer

IF 0.4 Q4 ONCOLOGY

Current Cancer Therapy Reviews Pub Date : 2023-03-21 DOI:10.2174/1573394719666230321153528

F. Rahmani, Mojde Atabati, Razieh Saber, Parnian Malakuti, Ghazaleh Pourali, Motahareh Heydari-majd, Pegah Safavi, Mohammad Dashti, Azam Rastgar Moghadam, M. Farazestanian, Negin Behboodi, M. Mehramiz, M. Nassiri, Majid Rajabian-Noghondar, R. Rahbarian, H. Ramshini, Amirhosein Jafarian, G. Ferns, A. Avan, M. Hasanzadeh

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引用次数: 2

Abstract

Cervical cancer is one of the most prevalent gynecologic cancers associated with high morbidity and mortality worldwide. There is mounting evidence indicating an association between the 9p21 locus genetic variants with susceptibility to various human malignancies. In this current study, we aimed to evaluate the potential relationship between the rs1333049 genetic variant in chromosome 9p21 and the risk of cervical carcinogenesis. Cervical cancer is one of the most prevalent gynecological cancers associated with high morbidity and mortality worldwide. There is mounting evidence indicating an association between the 9p21 locus genetic variants with susceptibility to various human malignancies. The possible correlation between rs1333049 polymorphism and susceptibility to cervical cancer was investigated in 221 patients with or without cancer. DNAs were isolated and genotyped using a TaqMan-based real-time RT-PCR method. The rs1333049 genetic variant was found to be correlated with an elevated risk of cervical neoplasia using recessive and additive genetic models (p<0.001). The possible correlation between rs1333049 polymorphism and susceptibility to cervical cancer was investigated in 221 patients with, or without cancer. DNAs were isolated and genotyped using a TaqMan-based real-time RT-PCR method. CDKN2A/B genetic variant (rs1333049) was significantly associated with an elevated risk of cancer, suggesting its potential as a novel predictive marker for cervical carcinogenesis. .

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染色体9p21基因变异与宫颈癌症发病风险增加的相关性

癌症是全球最常见的妇科癌症之一，发病率和死亡率较高。越来越多的证据表明，9p21基因座的遗传变异与各种人类恶性肿瘤的易感性之间存在关联。在本研究中，我们旨在评估染色体9p21中rs1333049基因变异与宫颈癌发生风险之间的潜在关系。癌症是全球最常见的妇科癌症之一，发病率和死亡率较高。越来越多的证据表明，9p21基因座的遗传变异与各种人类恶性肿瘤的易感性之间存在关联。对221例癌症患者rs1333049多态性与宫颈癌症易感性的相关性进行了研究。使用基于TaqMan的实时RT-PCR方法分离DNA并进行基因分型。应用隐性和加性遗传模型发现rs1333049基因变异与宫颈肿瘤风险升高相关（p＜0.001）。在221例癌症患者和非癌症的患者中研究了rs1333049.多态性与宫颈癌症易感性之间的可能相关性。使用基于TaqMan的实时RT-PCR方法分离DNA并进行基因分型。CDKN2A/B基因变异（rs1333049）与癌症风险升高显著相关，表明其有可能成为宫颈癌发生的新预测标志物。。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Cancer Therapy Reviews ONCOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.