Naturally-derived hydrogels for 3D pancreatic tumor models: A short review

Q2 Materials Science
Edyta Piłat, Agnieszka Kurdyn, Justyna Kucińska-Lipka
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引用次数: 0

Abstract

Statistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer drug development is emerging as a priority. Routinely used 2D culture models offer an initial evaluation of the therapeutic potential of a compound against tumors, while scaffold-free and next-generation scaffold-based 3D hydrogel-based models are found to be promising for appropriate mimicking of the tumor environment and cell interactions. Over the last few years, attention was paid to the use of naturally-derived hydrogel as 3D models for pancreatic tumor modeling. Herein we first overview scaffold-free and scaffold-based 3D tumor models as advanced approaches, followed by placing the focus on naturally-derived hydrogels applied as scaffolds in pancreatic cancer modeling. This short review emphasizes that sustainable hydrogels can almost precisely imitate the complex in vivo microenvironment of pancreatic tumor, thereby hydrogel-based scaffold tumor models may be a breakthrough in pancreatic cancer studies and, in result, significantly improve the poor pancreatic tumor survivability prognosis. Nevertheless, anticancer drug development might be overshadowed by using this family of biomaterials.
用于3D胰腺肿瘤模型的天然水凝胶:综述
统计数据表明,癌症是一种以高度异质性和复杂细胞外基质存在为特征的实体瘤,其死亡率较高。癌症治疗的低有效性源于该肿瘤的高转移潜能和耐药性。因此,寻找能够精确模拟体内条件的高效细胞模型和抗癌药物开发正成为当务之急。常规使用的2D培养模型提供了对化合物抗肿瘤治疗潜力的初步评估,而无支架和下一代基于支架的3D水凝胶模型被发现有希望适当模拟肿瘤环境和细胞相互作用。在过去的几年里,人们关注使用天然来源的水凝胶作为胰腺肿瘤建模的3D模型。在此,我们首先概述了无支架和基于支架的3D肿瘤模型作为先进方法,然后重点介绍了在胰腺癌症建模中用作支架的天然水凝胶。这篇简短的综述强调,可持续的水凝胶几乎可以精确地模仿胰腺肿瘤复杂的体内微环境,因此基于水凝胶的支架肿瘤模型可能是胰腺癌症研究的突破,从而显著改善胰腺肿瘤生存能力差的预后。然而,使用这种生物材料家族可能会使抗癌药物的开发黯然失色。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Polymers from Renewable Resources
Polymers from Renewable Resources Materials Science-Polymers and Plastics
CiteScore
3.50
自引率
0.00%
发文量
15
期刊介绍: Polymers from Renewable Resources, launched in 2010, publishes leading peer reviewed research that is focused on the development of renewable polymers and their application in the production of industrial, consumer, and medical products. The progressive decline of fossil resources, together with the ongoing increases in oil prices, has initiated an increase in the search for alternatives based on renewable resources for the production of energy. The prevalence of petroleum and carbon based chemistry for the production of organic chemical goods has generated a variety of initiatives aimed at replacing fossil sources with renewable counterparts. In particular, major efforts are being conducted in polymer science and technology to prepare macromolecular materials based on renewable resources. Also gaining momentum is the utilisation of vegetable biomass either by the separation of its components and their development or after suitable chemical modification. This journal is a valuable addition to academic, research and industrial libraries, research institutions dealing with the use of natural resources and materials science and industrial laboratories concerned with polymer science.
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