Evaluating bone biopsy quality by technique in an animal model

Research in diagnostic and interventional imaging Pub Date : 2022-06-01 DOI:10.1016/j.redii.2022.100008

Corey K Ho MD , David Gimarc MD , Hsieng-Feng Carroll PhD , Michael Clay MD , Jeffrey Schowinsky MD , MK Jesse MD , Amanda M Crawford MD , Carrie B Marshall MD

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引用次数: 1

Abstract

Rationale and Objectives

Powered bone biopsy technique is popular due to its ease of use. However, there is conflicting evidence regarding the diagnostic quality of the samples. The purpose of this study is to evaluate the diagnostic adequacy of different bone biopsy devices and techniques as it relates to the frequency of sample artifacts.

Materials and Methods

Bone biopsy was performed on same-day processed lamb femora using the following techniques: manual, pulsed powered and full powered. Ten samples were collected using each method by a single musculoskeletal-trained radiologist and were reviewed by 3 blinded pathologists. Samples were compared across multiple categories: length, bone dust, thermal/crush artifact, cellular morphology, fragmentation, and diagnostic acceptability. Bayesian Multilevel Nonlinear Regression models were performed assessing the association between the techniques across the categories.

Results

Statistical analysis revealed that the manual technique outperformed any powered technique across all categories: decreased thermal/crush artifact (P = 0.014), decreased bone dust (p<0.001), better cellular morphology (P = 0.005), less fragmentation (P < 0.0001) and better diagnostic acceptability (P < 0.0001).

Conclusion

Manually obtained bone biopsy samples generally produce a more diagnostic sample as compared to powered techniques in an animal model. Given these results, manual bone biopsy methods should be encouraged after consideration for lesion composition, difficulty of access and the patient's overall condition.

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用技术评价动物模型骨活检质量

原理和目的动力骨活检技术因其易于使用而广受欢迎。然而，关于样本的诊断质量存在相互矛盾的证据。本研究的目的是评估不同骨活检设备和技术的诊断充分性，因为它与样本伪影的频率有关。材料和方法采用手动、脉冲动力和全动力三种技术对当天处理的羔羊股骨进行骨活检。每种方法由一名受过肌肉骨骼训练的放射科医生采集10份样本，并由3名盲法病理学家进行审查。样本在多个类别中进行比较:长度、骨尘、热/挤压伪影、细胞形态、碎片和诊断可接受性。采用贝叶斯多水平非线性回归模型评估各类别技术之间的关联。结果统计分析显示，手工技术在所有类别中都优于任何动力技术:减少热/挤压伪像(P = 0.014)，减少骨尘(P = 0.001)，更好的细胞形态(P = 0.005)，更少的碎裂(P <0.0001)和更好的诊断可接受性(P <0.0001)。结论在动物模型中，与动力技术相比，人工获得的骨活检样本通常产生更有诊断价值的样本。鉴于这些结果，在考虑病变组成、进入难度和患者整体状况后，应鼓励人工骨活检方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research in diagnostic and interventional imaging Radiology and Imaging

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