{"title":"Chimeric antigen receptor-engineered adoptive cell therapy for AML: Current status and future perspectives","authors":"Yue Huang, Mi Shao, Yiyun Wang, He Huang","doi":"10.1002/imed.1031","DOIUrl":null,"url":null,"abstract":"<p>Acute myeloid leukemia (AML) is one of the lethal hematological malignancies with high relapse rates and poor prognosis. Since chimeric antigen receptor cellular therapy has exhibited remarkable therapeutic outcomes in B-cell malignancies, many studies have attempted to translate this success to other malignancies, including AML. Herein we review current achievements of chimeric antigen receptor-based cell therapy in AML preclinical studies and clinical trials with potential AML-associated cell markers. Furthermore, we discuss future prospects of chimeric antigen receptor-based cell therapy options for patients with AML.</p>","PeriodicalId":73348,"journal":{"name":"Immunomedicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/imed.1031","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Immunomedicine","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/imed.1031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
Acute myeloid leukemia (AML) is one of the lethal hematological malignancies with high relapse rates and poor prognosis. Since chimeric antigen receptor cellular therapy has exhibited remarkable therapeutic outcomes in B-cell malignancies, many studies have attempted to translate this success to other malignancies, including AML. Herein we review current achievements of chimeric antigen receptor-based cell therapy in AML preclinical studies and clinical trials with potential AML-associated cell markers. Furthermore, we discuss future prospects of chimeric antigen receptor-based cell therapy options for patients with AML.
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