Facile One-Step Synthesis of Nickel Sulphide Nanoparticles Decorated Poly (Acrylic Acid) Coated Multi-Walled Carbon Nanotube for Detection of Tenofovir in Human Urine

IF 2.7 4区化学 Q3 CHEMISTRY, PHYSICAL

Electrocatalysis Pub Date : 2022-11-09 DOI:10.1007/s12678-022-00784-w

John Alake, Zondi Nate, Darko Kwabena Adu, Blessing Wisdom Ike, Ruchika Chauhan, Rajshekhar Karpoormath

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引用次数: 1

Abstract

Tenofovir (TNF), a nucleotide analogue of adenosine 5′-monophosphate, is the first-line treatment for chronic HIV/hepatitis B coinfection. There is a need to explore highly sensitive, rapid, and cost-effective quality control techniques to detect the drug. Nickel sulphide @ poly(acrylic acid) coated multi-walled carbon nanotubes (NiS@PAA-MWCNT) composite was synthesized using the one-step solvothermal method. The composite was characterized by UV-vis spectroscopy, Fourier transforms infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and energy-dispersive X-ray spectroscopy. Morphological analysis showed polydispersed NiS on the surface of the poly(acrylic acid) coated multi-walled carbon nanotube (MWCNT). Tenofovir was electrochemically detected in human urine by differential pulse voltammetry (DPV) using the NiS@PAA-MWCNT modified glassy carbon electrode. The linear range was found to be from 20 to 80 µM with a limit of detection of 5.83 × 10⁻¹² M and 5.12 × 10⁻¹² M in phosphate buffer and human urine, respectively. The practical applicability of the modified electrode was evaluated in human urine and in the presence of different interfering agents. The electrode demonstrated good reproducibility, selectivity, and sensitivity. Thus, NiS@PAA-MWCNT nanocomposite can be used in electrochemical sensors for quality control purposes.

Graphical abstract

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硫化镍纳米粒子修饰聚丙烯酸包覆多壁碳纳米管一步合成检测人尿中替诺福韦

替诺福韦(TNF)是一种5′-单磷酸腺苷的核苷酸类似物，是慢性HIV/乙肝合并感染的一线治疗药物。有必要探索高灵敏度、快速、成本效益高的质量控制技术来检测该药物。采用一步溶剂热法合成了硫化镍@聚丙烯酸包被多壁碳纳米管(NiS@PAA-MWCNT)复合材料。采用紫外可见光谱、傅里叶变换红外光谱、扫描电镜、透射电镜、x射线衍射和能量色散x射线光谱对复合材料进行了表征。形态学分析表明，聚丙烯酸包覆的多壁碳纳米管(MWCNT)表面存在多分散的NiS。采用NiS@PAA-MWCNT改性玻碳电极，采用差分脉冲伏安法(DPV)对人尿中的替诺福韦进行电化学检测。在磷酸盐缓冲液和人尿中，检测限分别为5.83 × 10 - 12 M和5.12 × 10 - 12 M，线性范围为20 ~ 80µM。在人类尿液和不同干扰剂存在的情况下，评估了改进电极的实际适用性。该电极具有良好的重现性、选择性和灵敏度。因此，NiS@PAA-MWCNT纳米复合材料可用于电化学传感器的质量控制目的。图形抽象

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来源期刊

Electrocatalysis CHEMISTRY, PHYSICAL-ELECTROCHEMISTRY

CiteScore

4.80

自引率

6.50%

发文量

审稿时长

>12 weeks

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