Interrelationships between polymorphonuclear leukocytes (PMNs)- neutrophils, blood coagulation system and vascular endothelium during Covid-19 infection

Q4 Medicine

Series on Biomechanics Pub Date : 2022-04-01 DOI:10.7546/sb.18.2022

B. Bechev, S. Stoeff, K. Kavaldzhieva

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引用次数: 0

Abstract

Background. Polymorphonuclear leukocytes (PMNs-neutrophils) influence the processes of inflammation and immunity, participating in phagocytosis, cytoplasmic degranulation, NETosis, generation of reactive oxygen species (ROS), receptor-mediated communications with other cells and systems, innate and adaptive immunity, blood coagulation-and circulatory systems, etc. Neutrophils during development of Covid-19 disease. The participation of neutrophils during development, treatment and management of COVID-19 infection is evaluated and largely discussed in the scientific medical literature. The elevated neutrophil-to-lymphocyte ratio (NLR) and dynamic lowering of some routine blood parameters seem to be critical markers of severe COVID-19. Thus, dysregulation of immune system-with special participation of complement, leads to hyperproduction of cytokines and chemokines („cytokine storm”). The resulting pro-adhesive and prothrombotic effects stimulate further adhesion of leukocytes and platelets to the vascular endothelium, causing macro-and microvascular thromboses, capillary plugging and impaired microvascular flow. © 2022, Bulgarska Akademiya na Naukite. All rights reserved.

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多形核白细胞(PMNs)-中性粒细胞、凝血系统和血管内皮在Covid-19感染中的相互关系

背景多形核白细胞（PMNs-中性粒细胞）影响炎症和免疫过程，参与吞噬作用、细胞质脱颗粒、NETosis、活性氧（ROS）的产生、受体介导的与其他细胞和系统的通信、先天免疫和适应性免疫、凝血和循环系统等。新冠肺炎疾病发展过程中的中性粒细胞。中性粒细胞在新冠肺炎感染的发展、治疗和管理过程中的参与在科学医学文献中进行了评估和大量讨论。中性粒细胞与淋巴细胞比率（NLR）升高和一些常规血液参数的动态降低似乎是严重新冠肺炎的关键标志。因此，在补体的特殊参与下，免疫系统的失调会导致细胞因子和趋化因子的过度产生（“细胞因子风暴”）。由此产生的促粘附和促血栓形成作用刺激白细胞和血小板与血管内皮的进一步粘附，导致宏观和微血管血栓、毛细血管堵塞和微血管流动受损。©2022，Bulgarska Akademiya na Naukite。保留所有权利。

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来源期刊

Series on Biomechanics Medicine-Orthopedics and Sports Medicine

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The primary aims of the Journal “Series on Biomechanics” are to provide a means of communicating the advances being made in the areas of theoretical and applied biomechanics highlighting the interface with other multidisciplinary fields and with up-to-date technologies. The Journal will also focus for the importance of new ideas and useful applications in different areas, in order to assure a valuable impact of the biomechanics on the knowledge and the know-how in the future.