Practice Patterns of Palmoplantar Pustulosis: Patient Demographics and Treatment Options.

Q3 Medicine
Antoinette Chandler, Hannah Wood, Novin Nezamololama, Melinda J Gooderham
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引用次数: 0

Abstract

Background: Palmoplantar pustulosis (PPP) is a chronic skin condition characterized by sterile pustules on the palms and soles. This condition is more commonly reported among women and smokers causing considerable discomfort and interference with daily activities. Although there are various off-label treatment options available for PPP, there remains a demand to identify more effective and safer treatments.

Objective: To review the patient demographics and treatment patterns of our PPP patient population.

Methods: A retrospective chart review was performed at a dermatology office with two locations in Ontario, Canada.

Results: We identified 71 adult PPP patients. A third of patients did not return for follow up after diagnosis. Among those who returned for follow-up, 20% were managed with topical therapy alone. Of our patients who took systemic treatment for PPP, apremilast, followed by ustekinumab and guselkumab, had the greatest retention of therapy.

Conclusion: Targeting PDE4, IL-12/23 and IL-23 provided some benefit for our patients with PPP leading to greatest retention of therapy over time. Further investigation is required into the cause for high no-show rates and the search for effective and safe treatment options.

掌跖Pustulosis的实践模式:患者人口学和治疗方案
背景掌跖脓疱病(PPP)是一种以手掌和足底无菌性脓疱为特征的慢性皮肤病。这种情况在女性和吸烟者中更为常见,会引起相当大的不适,并干扰日常活动。尽管PPP有各种标签外治疗选择,但仍需要确定更有效、更安全的治疗方法。目的回顾我国PPP患者群体的人口统计学特征和治疗模式。方法在加拿大安大略省的两个皮肤科办公室进行回顾性图表审查。结果我们确定了71名成年PPP患者。三分之一的患者在确诊后没有返回进行随访。在那些返回随访的患者中,20%的患者仅接受了局部治疗。在我们接受PPP系统治疗的患者中,阿普司特,其次是ustekinumab和guselkumab,治疗保留率最高。结论靶向PDE4、IL-12/23和IL-23为PPP患者提供了一些益处,随着时间的推移,治疗保留率最高。需要对高无症状率的原因进行进一步调查,并寻找有效和安全的治疗方案。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
19
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