Thrombogenic indices in an evaluation of pregnant Nigerian women with pregnancy loss

H. Okoye, J. Chinawa, E. Aniwada, L. Eweputanna, T. Nwagha, U. Nwagha
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引用次数: 1

Abstract

Background: Pregnancy losses (PLs) are usually a source of pain and psychological stress to the expectant couples. The association between ABO blood groups and some thrombogenic markers with PL among Nigerian women is mostly unknown. Aim: This study investigates the association between ABO blood group, deficiencies of protein C (PC), and protein S (PS) and PL. Patients and Methods: A cross-sectional study involving 170 pregnant women grouped into two, those with or without a history of clinically- or ultrasonographically recognizable PL. ABO blood groups using the tile method, plasma concentrations of free protein S (fPS) antigen, protein C antigen (PCAg) by the enzyme-linked immunosorbent assay-based method, and PC activity (PCAc) by PROTAC method was determined. Results: There was no difference in mean values between the two groups for PCAg, PCAc, FPS, and blood group (P > 0.05). The chances of PL were; non-O blood group (AOR 1.29; 95% CI 0.65--2.54), deficient PCAg (AOR 1.75; 95% CI 0.87--3.54), and deficient PCAc (AOR 1.05;95%CI 0.25--4.13). There was a very poor correlation of miscarriage with FPS (rho 0.04), PCAg (rho 0.09), and PCAc (rho = 0.05). Conclusion: There was no significant association between PLs and ABO blood group phenotypes, PCAg, PCAc, fPS.
血栓形成指数在评估尼日利亚流产孕妇中的作用
背景:妊娠损失(PLs)通常是一个来源的痛苦和心理压力的准夫妇。在尼日利亚妇女中,ABO血型和一些血栓形成标志物与PL之间的关系大多是未知的。目的:探讨ABO血型与蛋白C (PC)缺乏、蛋白S (PS)和PL缺乏的关系。一项横断研究纳入170名孕妇,分为两组,有或没有临床或超声可识别的PL病史。采用tile法测定ABO血型,采用酶联免疫吸附法测定血浆游离蛋白S (fPS)抗原、蛋白C抗原(PCAg)浓度,采用PROTAC法测定血浆PC活性(PCAc)。结果:两组患者PCAg、PCAc、FPS、血型的平均值比较,差异无统计学意义(P < 0.05)。PL的概率是;非o型血(AOR 1.29;95% CI 0.65—2.54),PCAg缺陷(AOR 1.75;95%CI 0.87—3.54)和PCAc缺陷(AOR 1.05;95%CI 0.25—4.13)。流产与FPS (rho 0.04)、PCAg (rho 0.09)、PCAc (rho = 0.05)相关性极低。结论:PLs与ABO血型表型、PCAg、PCAc、fPS无显著相关性。
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