Berberine: A plant derived alkaloid with therapeutic potential to combat Alzheimer's disease.

Q3 Psychology

Central nervous system agents in medicinal chemistry Pub Date : 2019-11-30 DOI:10.2174/1871524919666190820160053

A. Singh, S. Singh, M. Nandi, G. Mishra, Anand Maurya, Arati Rai, G. K. Rai, R. Awasthi, Bhupesh Sharma, G. Kulkarni

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引用次数: 44

Abstract

Berberine (A protoberberine isoquinoline alkaloid) has shown promising pharmacological activities, including analgesic, anti-inflammatory, anticancer, antidiabetic, anti-hyperlipidemic, cardioprotective, memory enhancement, antidepressant, antioxidant, anti-nociceptive, antimicrobial, anti-HIV and cholesterol-lowering effects. It is used in the treatment of neurodegenerative disorder. It has strong evidence to serve as potent phytoconstituent in the treatment of various neurodegenerative disorders such as AD. It limits the extracellular amyloid plaques and intracellular neurofibrillary tangles. It also has lipid-glucose lowering ability, hence can be used as a protective agent in atherosclerosis and AD. However, more detailed investigations along with safety assessment of berberine are warranted to clarify its role in limiting various risk factors and AD-related pathologies. This review highlights the pharmacological basis to control oxidative stress, neuroinflammation and protective effect of berberine in AD, which will benefit to the biological scientists in understanding and exploring the new vistas of berberine in combating Alzheimer's disease.

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小檗碱:一种从植物中提取的生物碱，具有治疗阿尔茨海默病的潜力。

小檗碱(一种原小檗碱类异喹啉生物碱)具有镇痛、抗炎、抗癌、降糖、抗高脂血症、保护心脏、增强记忆、抗抑郁、抗氧化、抗伤害、抗菌、抗艾滋病毒和降低胆固醇等药理作用。它被用于治疗神经退行性疾病。它有强有力的证据，作为有效的植物成分在治疗各种神经退行性疾病，如阿尔茨海默病。它限制了细胞外淀粉样斑块和细胞内神经原纤维缠结。它还具有降脂降糖能力，因此可以作为动脉粥样硬化和AD的保护剂。然而，需要对小檗碱进行更详细的研究和安全性评估，以明确其在限制各种风险因素和ad相关病理方面的作用。本文综述了小檗碱在阿尔茨海默病中控制氧化应激、神经炎症和保护作用的药理基础，有助于生物学家认识和探索小檗碱抗阿尔茨海默病的新前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology

CiteScore

2.10

自引率

0.00%

发文量

期刊介绍： Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.