The changes and significance of the soluble B cell-activating factor in the peripheral blood of patients with chronic human immunodeficiency virus infection

中华传染病杂志 Pub Date : 2018-09-15 DOI:10.3760/CMA.J.ISSN.1000-6680.2018.09.006

Xingzhong Hu, W. Kong, Guiqing He, Jichan Shi, Xiaoya Cui

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Abstract

Objective To elaborate the changes of the soluble B cell-activating factor of the tumor necrosis factor family (BAFF) in the peripheral blood of chronic human immunodeficiency virus (HIV)-infected patients, and to study the correlation between the soluble BAFF in HIV-infected patients and the progressions of acquired immune deficiency syndrome (AIDS). Methods Fifty untreated HIV outpatients and 30 healthy controls were recruited. According to the counts of CD4+ T lymphocytes, HIV-infected patients were divided into three groups, 350 cells/μL group. B cell counts and the BAFF levels were compared among the three groups and the healthy controls. The correlation analysis was conducted for the levels of BAFF, the counts of CD4+ T lymphocytes and B cells, and viral load in HIV-infected patients. The value of BAFF in staging of HIV disease was identified by receiver operating characteristic (ROC) curve. Results The B cell counts were (90.3±43.1) cells/μL in 350 cells/μL group and (307.1±97.0) cells/μL in healthy controls, which was significantly different among the four groups (F=47.92, P<0.05). The concentrations of BAFF in the four groups were (1 737.5±719.7), (962.8±341.1), (859.8±270.4), and (456.9±163.7) ng/L, with significant difference among the groups (F=36.72, P<0.05). The level of BAFF was negatively correlated with both B cell counts and CD4+ T lymphocyte counts (r=-0.722 and -0.568, respectively; both P<0.05), and positively correlated with viral load (r=0.607, P<0.05). The area under the ROC curve was 0.881. If the level of BAFF was 1 281.5 ng/L, the sensitivity and specificity to predict the period of AIDS were 74.1% and 87.0%, respectively. Conclusion The levels of soluble BAFF in HIV-infected patients are significantly increased and related with the reduction of B cell counts and disease progression. Key words: HIV-1; B-lymphocytes; BAFF

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慢性人类免疫缺陷病毒感染患者外周血可溶性B细胞活化因子的变化及意义

目的探讨慢性免疫缺陷病毒（HIV）感染者外周血中肿瘤坏死因子家族可溶性B细胞活化因子（BAFF）的变化，探讨HIV感染者可溶性B细胞激活因子与获得性免疫缺陷综合征（AIDS）进展的相关性。方法选择50例未经治疗的HIV门诊患者和30例健康对照者。根据CD4+T淋巴细胞计数，将HIV感染者分为三组，350细胞/μL组。比较三组和健康对照组之间的B细胞计数和BAFF水平。对HIV感染患者的BAFF水平、CD4+T淋巴细胞和B细胞计数以及病毒载量进行相关性分析。BAFF在HIV疾病分期中的价值通过受试者操作特征（ROC）曲线来确定。结果350细胞/μL组的B细胞计数为（90.3±43.1）个细胞/μL，健康对照组为（307.1±97.0）个细胞-μL，四组间差异有统计学意义（F=47.92，P<0.05）。四组BAFF浓度分别为（737.5±719.7）、（962.8±341.1）、（859.8±270.4）和（456.9±163.7）ng/L，BAFF水平与B细胞计数和CD4+T淋巴细胞计数均呈负相关（r=-0.722和-0.568，均P<0.05），与病毒载量呈正相关（r=0.607，P<0.05），ROC曲线下面积为0.881。如果BAFF水平为1 281.5 ng/L，则预测艾滋病病程的敏感性和特异性分别为74.1%和87.0%。结论HIV感染者可溶性BAFF水平显著升高，与B细胞计数减少和疾病进展有关。关键词：HIV-1；B淋巴细胞；BAFF

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来源期刊

中华传染病杂志

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发文量

5280

期刊介绍： The Chinese Journal of Infectious Diseases was founded in February 1983. It is an academic journal on infectious diseases supervised by the China Association for Science and Technology, sponsored by the Chinese Medical Association, and hosted by the Shanghai Medical Association. The journal targets infectious disease physicians as its main readers, taking into account physicians of other interdisciplinary disciplines, and timely reports on leading scientific research results and clinical diagnosis and treatment experience in the field of infectious diseases, as well as basic theoretical research that has a guiding role in the clinical practice of infectious diseases and is closely integrated with the actual clinical practice of infectious diseases. Columns include reviews (including editor-in-chief reviews), expert lectures, consensus and guidelines (including interpretations), monographs, short monographs, academic debates, epidemic news, international dynamics, case reports, reviews, lectures, meeting minutes, etc.