Targeting reservoirs of HIV replication in lymphoid follicles with cellular therapies to cure HIV

Abstract

There is a need to create improved treatments for HIV infection. Growing evidence indicates that HIV treatment strategies must target and reduce viral replication in lymphoid follicles where HIV replication is most concentrated. In this mini-review, three cell therapy approaches are described: CAR-T and CAR-NK cells, adoptive transfer of autologous HIV-specific T cells, and HIV-resistant cells. The potential for these innovative strategies to reduce viral replication in follicles and the potential of combining cell therapies with other treatment strategies to achieve a complete eradication of HIV is discussed.