Correlation of laboratory parameters and computed tomography findings in real-time reverse transcriptase-polymerase chain reaction-negative individuals

Abstract

Context: The diagnosis of COVID-19 relies on the reverse transcriptase-polymerase chain reaction (RT-PCR) obtained from the respiratory tract secretions. Due to various factors, there is a possibility of getting an inaccurate result. The false-negative result would be dangerous as the affected individual would not be subjected to quarantine and would go on to infect others. Hence, there is a need for an alternative in diagnosing COVID-19. Aims: To assess the correlation of computed tomography (CT) findings, laboratory parameters, and outcomes in COVID-19 suspect patients. Design: The study design involves retrospective study. Materials and Methods: RT-PCR-negative COVID suspect individuals were taken. Laboratory parameters such as serum ferritin, serum lactate dehydrogenase (LDH), serum D-dimer, and serum C-reactive protein (CRP) were considered. CT findings in these patients were determined. These parameters were statistically analyzed. Statistical Analysis Used: Frequency, percentage distribution, mean standard deviation, median, interquartile range, and Kruskal–Wallis test. Results: There was a statistically significant correlation between the serum LDH, serum ferritin, and serum CRP with the CT severity findings in RT-PCR-negative COVID suspect individuals. The predominant CT finding was ground-glass opacities. Conclusions: In conclusion, the laboratory parameters and CT findings can be used as an alternative in the diagnosis of COVID-19 in RT-PCR-negative individuals.