The adverse impact of Aloe Vera gel extract and Aloe Vera-fortified yogurt on hepatic and renal functions

Enas Mamdouh, M. Youssef
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Abstract

Aloe Vera gel is used to ameliorate medical complications such as inflammation, wounds, and diabetes. It is utilized as a dairy products supplement to potentiate its nutritive value. However, Aloe Vera was reported as a potential irritant for hepatic and renal tissues. In this study, we investigated the impact of different concentrations of Aloe Vera gel extract alone or as a supplement to yogurt on hepatic and renal functions. Thirty-six male albino rats were randomly divided into six groups (n = 6). The groups received either oral administration of distilled water (DW/Control), Aloe Vera gel 10% in DW (AV10), Aloe Vera gel 20% (AV20), plain yogurt (Y), yogurt supplemented with 10% Aloe Vera gel extract (Y+AV10), or yogurt supplemented with 20% Aloe Vera gel extract (Y+AV20). Treatment was carried out daily for one week. Renal and hepatic biochemical parameters were assessed. ALT was significantly increased in the AV20 group compared to the control and AV10 groups. AST level was significantly high in Y+AV20 compared to Y+AV10, Y, and DW groups . No changes were observed in creatinine and urea. Hepatic micrographs showed vacuolar degeneration of hepatocytes in the AV20 group, while the Y+AV20 group showed necrosis of parenchyma and individualization of hepatocytes. No significant tissue changes were observed in the kidney. In conclusion, Aloe Vera gel extract, especially with higher concentrations, is irritant to the liver of rats with no prominent impact on the kidney. Moreover, yogurt failed to ameliorate the drastic impact of Aloe Vera on hepatic functions.
芦荟凝胶提取物和芦荟强化酸奶对肝肾功能的不利影响
芦荟凝胶用于改善并发症,如炎症、伤口和糖尿病。它被用作乳制品补充剂,以增强其营养价值。然而,据报道,芦荟对肝脏和肾脏组织有潜在的刺激作用。在这项研究中,我们研究了不同浓度的芦荟凝胶提取物单独或作为酸奶补充剂对肝肾功能的影响。36只雄性白化大鼠被随机分为6组(n=6)。各组接受蒸馏水(DW/对照)、10%的芦荟凝胶DW(AV10)、20%的芦荟凝胶AV20、纯酸奶Y、补充10%芦荟凝胶提取物的酸奶Y+AV10或补充20%芦荟凝胶提取物(Y+AV20)的酸奶的口服给药。每天进行治疗,持续一周。评估肾脏和肝脏的生化参数。与对照组和AV10组相比,AV20组的ALT显著升高。与Y+AV10、Y和DW组相比,Y+AV20组的AST水平显著升高。肌酸酐和尿素没有变化。肝脏显微照片显示AV20组肝细胞空泡变性,而Y+AV20组显示肝实质坏死和肝细胞个体化。肾脏中未观察到明显的组织变化。总之,芦荟凝胶提取物,特别是浓度较高的芦荟凝胶提取物对大鼠肝脏有刺激性,对肾脏没有显著影响。此外,酸奶未能改善芦荟对肝功能的剧烈影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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16 weeks
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