Efficacy of soluble hyaluronic acid microneedle on removing suborbital wrinkles

中华医学美学美容杂志 Pub Date : 2019-12-15 DOI:10.3760/CMA.J.ISSN.1671-0290.2019.06.010

Yan Zhao, L. Xiang, Hui Xu, Jianzhong Zhang

{"title":"Efficacy of soluble hyaluronic acid microneedle on removing suborbital wrinkles","authors":"Yan Zhao, L. Xiang, Hui Xu, Jianzhong Zhang","doi":"10.3760/CMA.J.ISSN.1671-0290.2019.06.010","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the clinical efficacy and safety of soluble hyaluronic acid microneedle eye patch on infraorbital wrinkles. \n \n \nMethods \nSeventy-five female subjects in Beijing and Shanghai were recruited and treated with soluble hyaluronic acid microneedle patch two days a week at the left lower eyelid (experimental side) and at least 30 minutes each time for 12 weeks. Investigator visual assessment, instrumentation measurement for skin moisture, elasticity, wrinkle area and depth were performed at week 0 (pre-treatment) and week 4 and week 12 and compared to the right (control side). The safety was assessed by documenting adverse reactions occurring during the study. Subject satisfaction was assessed at week 12. \n \n \nResults \nAfter 12 weeks of treatment, the visual assessment of skin wrinkles on experimental side (n=41, 54.67%) was significantly improved as comparied with that on control side (n=14, 18.67%). The skin hydration of treatment side skin increased with treatment time (t=-0.488 at week4, t=-3.054 at week 12, P<0.05). After 12 weeks of treatment, skin elasticity of the experimental side improved significantly. The improvement rate of the experimental side was more than that of the control side (t=2.724, P<0.05). The wrinkle area was significantly decreased in 4 and 12 weeks compared with pre-treatment (t=4.442 at week 4 and t=3.802 at week 12, P<0.001). The depth of wrinkles of the experimental side shallowed with the treatment (t=-2.435 at week 4 and t=-3.433 at week 12, P<0.05). Only 8% (n=6) of the subjects had temporary slight pruritus or acupuncture sensation on the treatment side, and no other adverse reactions occurred. The overall subject satisfaction rate was 88%(n=66). \n \n \nConclusions \nSoluble hyaluronic acid microneedle eye patch is effective in improving wrinkles, skin elasticity and hydrating, and has no obvious adverse reaction. \n \n \nKey words: \nHyaluronic acid; Solublemicroneedles; Suborbitalwrinkle; Skin elasticity; Skin hydration","PeriodicalId":10094,"journal":{"name":"中华医学美学美容杂志","volume":"25 1","pages":"478-481"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华医学美学美容杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1671-0290.2019.06.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 1

Abstract

Objective To investigate the clinical efficacy and safety of soluble hyaluronic acid microneedle eye patch on infraorbital wrinkles. Methods Seventy-five female subjects in Beijing and Shanghai were recruited and treated with soluble hyaluronic acid microneedle patch two days a week at the left lower eyelid (experimental side) and at least 30 minutes each time for 12 weeks. Investigator visual assessment, instrumentation measurement for skin moisture, elasticity, wrinkle area and depth were performed at week 0 (pre-treatment) and week 4 and week 12 and compared to the right (control side). The safety was assessed by documenting adverse reactions occurring during the study. Subject satisfaction was assessed at week 12. Results After 12 weeks of treatment, the visual assessment of skin wrinkles on experimental side (n=41, 54.67%) was significantly improved as comparied with that on control side (n=14, 18.67%). The skin hydration of treatment side skin increased with treatment time (t=-0.488 at week4, t=-3.054 at week 12, P<0.05). After 12 weeks of treatment, skin elasticity of the experimental side improved significantly. The improvement rate of the experimental side was more than that of the control side (t=2.724, P<0.05). The wrinkle area was significantly decreased in 4 and 12 weeks compared with pre-treatment (t=4.442 at week 4 and t=3.802 at week 12, P<0.001). The depth of wrinkles of the experimental side shallowed with the treatment (t=-2.435 at week 4 and t=-3.433 at week 12, P<0.05). Only 8% (n=6) of the subjects had temporary slight pruritus or acupuncture sensation on the treatment side, and no other adverse reactions occurred. The overall subject satisfaction rate was 88%(n=66). Conclusions Soluble hyaluronic acid microneedle eye patch is effective in improving wrinkles, skin elasticity and hydrating, and has no obvious adverse reaction. Key words: Hyaluronic acid; Solublemicroneedles; Suborbitalwrinkle; Skin elasticity; Skin hydration

查看原文本刊更多论文

可溶性透明质酸微针去除眶下皱纹的疗效观察

目的探讨可溶性透明质酸微针眼罩治疗眶下皱纹的临床疗效和安全性。方法北京和上海的75名女性受试者，每周2天（实验侧）在左下眼睑使用可溶性透明质酸微针贴片，每次至少30分钟，持续12周。在第0周（预处理）、第4周和第12周进行研究者视觉评估，仪器测量皮肤水分、弹性、皱纹面积和深度，并与右侧（对照侧）进行比较。通过记录研究期间发生的不良反应来评估安全性。在第12周评估受试者满意度。结果治疗12周后，实验侧（n=41，54.67%）皮肤皱纹的视觉评估与对照侧（n=14，18.67%）相比有显著改善。治疗侧皮肤的水合作用随着治疗时间的延长而增加（t=-0.488，t=-3.054，P<0.05），实验侧皮肤弹性明显改善。实验侧的改善率高于对照侧（t=2.724，P<0.05）。与治疗前相比，第4周和第12周皱纹面积显著减少（第4周t=4.442，第12周t=3.802，P<0.001）。实验侧的皱纹深度随着治疗而变浅（第4周t=-2.435，第12周t=-3.433，P<0.05）受试者在治疗侧有短暂的轻微瘙痒或针刺感觉，没有发生其他不良反应。受试者的总体满意度为88%（n=66）。结论可溶性透明质酸微针眼罩对改善皱纹、皮肤弹性和补水效果显著，无明显不良反应。关键词：透明质酸；可溶性微针；眶下皱纹；皮肤弹性；皮肤水合作用

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华医学美学美容杂志

自引率

0.00%

发文量

4641

期刊介绍： "Chinese Journal of Medical Aesthetics and Cosmetology" is a high-end academic journal focusing on the basic theoretical research and clinical application of medical aesthetics and cosmetology. In March 2002, it was included in the statistical source journals of Chinese scientific and technological papers of the Ministry of Science and Technology, and has been included in the full-text retrieval system of "China Journal Network", "Chinese Academic Journals (CD-ROM Edition)" and "China Academic Journals Comprehensive Evaluation Database". Publishes research and applications in cosmetic surgery, cosmetic dermatology, cosmetic dentistry, cosmetic internal medicine, physical cosmetology, drug cosmetology, traditional Chinese medicine cosmetology and beauty care. Columns include: clinical treatises, experimental research, medical aesthetics, experience summaries, case reports, technological innovations, reviews, lectures, etc.