Prevention of pre-eclampsia with low dose aspirin in primigravida

Abstract

Pre-eclampsia is a multi-system disorder of pregnancy associated with hypertension and proteinuria. Its incidence varies between 2-10%, depending on the population studied. Moreover, it is the second leading cause of direct maternal and fetal deaths in Pakistan.1 Although, there is obvious predisposition in certain people to develop pre-eclampsia, the risk is 5-7% among primigravida women.2 Further, while the origin of the pre-eclampsia remains unclear, it is believed that pre-eclampsia is associated with the deep placentation disorders. The physiological change-over of uterine spiral arteries between 8-16weeks of gestation is the classical placental disorder associated with the pre-eclampsia.3 Moreover; elevated platelet triggering is the set component of pathophysiology of pre-eclampsia. This may persuade to platelet utilization and ensuing the microvasculature’s coagulation system set off, which sequentially leads to endothelial injury, vasospasm and end organ damage.