The effects of Elaeagnus angustifolia L. whole fruit on the sex hormone profile in menopausal women: A double-blind, randomized, placebo-controlled study
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引用次数: 4
Abstract
Ethnopharmacological relevance
Menopause is a product of interrupted ovarian activity and decrease in its estradiol production. Herbal medicines as an alternative to hormone therapy are increasingly used by menopausal women. Elaeagnus angustifolia L. (Senjed in Persian) is a well-known herbal remedy with various therapeutic effects according to Iranian traditional medicine which is recommended to relieve the menopausal side effects. The aim of present study was to evaluate the effects of oral intake of whole fruit powder of E. angustifolia on the sex hormones profile in menopausal women.
Materials and methods
In present double-blind randomized placebo-controlled trial, 58 eligible women who were referred to Kamali Women Hospital (Karaj, Iran, 2017) were randomly assigned into herbal medicine (15 g E. angustifolia) and placebo (7.5 g cornstarch +7.5 g isomalt) groups. Initially and after 10 weeks of the treatment, serum levels of estradiol, progesterone, testosterone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH) hormones were measured.
Results
According to between-group analyses, the changes in the studied parameters were not significant between herbal medicine and placebo groups, except for joint pain that improved significantly in herbal medicine group. However, by within-group analysis the levels of FSH and FSH to testosterone showed a significant increase, whereas the level of progesterone decreased significantly after 10 weeks of E. angustifolia consumption.
Conclusions
The improvement of the sex hormone profile was not in a full accordance with Iranian folklore after E. angustifolia consumption in the present menopausal participants. However, considering a strong belief on the beneficial effects of E. angustifolia in Iranian folklore, a long-term studies of larger group participants are needed to evaluate the efficacy.
绝经是卵巢活动中断和雌二醇分泌减少的产物。草药作为激素治疗的替代品越来越多地被更年期妇女使用。Elaeagnus angustifolia L.(波斯语Senjed)是一种众所周知的草药，根据伊朗传统医学，它具有多种治疗效果，被推荐用于缓解更年期副作用。本研究的目的是评价口服荷叶全果粉对绝经期妇女性激素水平的影响。材料与方法在本双盲随机安慰剂对照试验中，58名转介至Kamali妇女医院(Karaj, Iran, 2017)的符合条件的妇女被随机分为中草药组(15 g E. angustifolia)和安慰剂组(7.5 g玉米淀粉+7.5 g异麦芽糖)。治疗初期和治疗10周后，测定血清雌二醇、孕酮、睾酮、促卵泡激素(FSH)和黄体生成素(LH)水平。结果经组间分析，中药组与安慰剂组除关节疼痛明显改善外，其余各指标均无显著变化。然而，通过组内分析，FSH和FSH对睾酮的水平在食用10周后显著升高，而孕酮水平显著下降。结论绝经期妇女食用黄芪后性激素水平的改善并不完全符合伊朗民间传说。然而，考虑到在伊朗民间传说中对安古斯提叶有益作用的强烈信念，需要对更大群体参与者进行长期研究来评估其功效。
期刊介绍：
The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.
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