Correlation between Skin Prick Test and Specific IgE of Local Mites Allergen in Atopic Dermatitis Patients: an Indonesian Study

Abstract

Abstract There are two methods that can be used to detect the causative of allergen that trigger the occurrence of Atopic Dermatitis (AD): skin prick test (SPT) and specific IgE (sIgE). Indonesia has developed SPT using local allergens extract to be used as an allergen diagnostic tool. This study aims to determine the correlation between local SPT from Indonesia and sIgE of mites. As many as 45 subjects who met the inclusion criteria were included in this study. Skin prick test was evaluated twice, one week apart. The first SPT was done with standard SPT, and second SPT with local SPT. The sIgE examination was examined at the second week, after performing SPT with local allergen extracts. The subjects in this study were 18-60 years old and dominated by females (75.56%). The three diagnostic tools used in this study showed the same clinical relevance (68.89%). From the mites sIgE examination, it was found that Tyrophagus putrescentiae was the most common sensitized allergen found in positive mites SPT (57.78%). The results of this showed significant results (P <0.05) and moderate correlation (r = 0.40-0.69) between sIgE class and wheal diameter of local SPT on mites allergen. This study found that local SPT from Indonesia has good clinical relevance and positive correlation with other diagnostic tools that already exist, therefore can be considered as a diagnostic tool for determining the cause of atopic dermatitis in the future. Keywords: Atopic dermatitis, Skin prick test, Specific IgE, Human and disease.